脑死亡诱发肺损伤机制及治疗进展  

Advancement in Mechanism and Treatment on Lung Injury Induced Brain Death Induced Brain Death

作　　者：付志杰[1] 周华成[1] 李文志[1] 

机构地区：[1]哈尔滨医科大学附属第二医院麻醉科黑龙江省麻醉与危重病学研究重点实验室,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2012年第22期4373-4375,4372,共4页Progress in Modern Biomedicine

基　　金：中国博士后基金特别资助项目(201104453)

摘　　要：肺移植是终末期肺疾病的最终治疗方案。供体短缺是肺移植所面临的主要问题。目前,脑死亡供体是肺移植供体的重要来源。然而,脑死亡过程会诱发急性肺损伤并且加重肺缺血再灌注损伤。脑死亡肺损伤机制主要包括三个方面:血流动力学的剧烈改变、全身炎症改变、神经内分泌的改变。其肺损伤表现于肺间质水肿、血浆外漏和肺泡出血,造成肺水肿等。深入探索脑死亡肺损伤的机制,将对治疗及实施肺保护提供有力的依据。Lung transplantation has become an effective and a widely accepted clinical treatment for patients with end-stage pulmonary diseases.The shortage of suitable donors is one of difficulties which are faced by lung transplantation.Brain-dead（BD） donor is the major source of lung transplantation in recent years.Brain death is followed by devastating hemodynamic,inflammatory and neurohumoral reactions in the potential donor which not only infict direct damage,but also induce activation of the immune system which can cause rejection or even graft failure.BD-induced lung injuries include massive interstitial edema,hemorrhage,and intra-alveolar deposits,which makes the lung susceptible to ischemia-reperfusion injury,primary graft dysfunction,and chronic rejection.Hence,alleviating BD-induced injuries can improve the outcome of lung transplantations.Further exploration of the mechanism of brain death induced lung injury will provide strong basis for the implementation of lung protection.

关 键 词：脑死亡 供体 肺保护 

分 类 号：R617[医药卫生—外科学]