桑仙降压颗粒对自发性高血压大鼠心脏超微结构的作用  

Impact of Compound Sang Xian Granules on Cardiac Ultrastructure of Spontaneously Hypertensive Rat

作　　者：张蕴慧[1] 

机构地区：[1]山东省中医院心内科

出　　处：《世界中医药》2012年第4期355-357,共3页World Chinese Medicine

基　　金：山东省中青年科学家基金课题(编号:2006BS03047);山东省自然基金课题(编号:30873241)

摘　　要：目的:观察桑仙降压颗粒对自发性高血压大鼠(SHR)血压及心脏超微结构的作用。方法:以wistar为正常对照、SHR灌服蒸馏水为空白对照、吲哒帕胺为西药对照组,桑仙降压颗粒为降压组,于实验0周、4周、8周时测量各组大鼠尾动脉收缩压,电镜观测心脏超微结构。结果:与空白对照组相比,桑仙降压组、吲哒帕胺组实验4、8周血压明显降低。在心脏超微结构观测中,4周龄SHR开始出现少数线粒体肿胀,实验4周后线粒体灶性聚集,实验8周心肌肌原纤维灶性溶解,线粒体嵴碎裂溶解;桑仙降压组于实验8周后心肌肌原纤维局部出现皱缩、缺失,线粒体灶性聚集;吲哒帕胺组实验8周心肌肌原纤维灶性溶解,线粒体灶性聚集、肿胀,部分嵴开始溶解。结论:桑仙降压颗粒有效降低SHR血压,对心脏超微结构的保护作用优于吲哒帕胺。Objective：To investigate the effect of Compound Sang Xian Granule on blood pressure （BP） and cardiac ultrastructure of spontaneously hypertensive rats （SHR）. Methods：The treatment group gavaged with Compound Sang Xian Grannule was compared with normal control group, control group gavaged with distilled water, positive control group gavaged with indapamide. BP was measured and cardiac uhrastructure was observed at the weekO, week4, week8. Results： Compared with blank control group, Compound Sang Xian Granule and Indapamide significantly decreased BP at week4 and week8. Ch0ndriosome began to swell when SHR was 4 weeks old, after 4 weeks the mitoehondrion focally aggregated, and the myofibrils and erista mitochondriales focally dissolved at week 8. In the experimental group, part of cardiac myofibrils collapsed focally, chondriosome focally aggregated at the 8th week. The change of the control group was more obvious than the experimental group. Conclusion： Compound Sang Xian Granules can control blood pressure in spontaneously hypertensive rats, and acts better than Indapamide on ultra-structure of the heart.

关 键 词：桑仙降压颗粒 心脏 超微结构 

分 类 号：R544.1[医药卫生—心血管疾病]