鲜地黄配方颗粒成型工艺优选  

Optimization of Molding Process for Fresh Rehmannia glutinosa Formula Granule

作　　者：苏玉贞[1] 邹慧琴[1] 张志强 李健[1] 杨晓芸[1] 闫永红[1] 

机构地区：[1]北京中医药大学,北京100102 [2]北京康仁堂药业有限公司,北京101300

出　　处：《中国实验方剂学杂志》2012年第17期50-53,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨鲜地黄配方颗粒的成型工艺。方法:以制粒粒度、堆密度、流动性、溶化性、吸湿性为指标,考察不同辅料种类及辅料用量;以软材性状、制粒难易程度、成品性状为指标,考察不同体积分数乙醇,优选适宜润湿剂。结果:最佳制粒工艺为干燥粉与麦芽糊精按1∶1比例混匀,以85%乙醇为润湿剂制软材,1号药筛挤压制粒,60℃干燥,整粒。成品颗粒的临界相对湿度60%。结论:该优选工艺方法简便易行,成品率高,为鲜地黄配方颗粒大生产提供实验依据。Objective： To investigate molding process of fresh Rehmannia glutinosa formula granule. Method： Kinds and consumption of accessories were investigated with particle size, bulk density, mobility, melting and moisture absorption as indexes; The concentrations of ethanol and optimum wetting agent were investigated with soft material properties, difficulty degree of granulation, product character as indicators. Result： Optimum granulation process was： mixing ratio of dry powder-maltodextrin 1： 1, 85% ethanol as wetting agent to make soft material, extrusion granulation with one drug sieve, dried at 60℃ , sorting particle. Critical relative humidity of product particles was 60%. Conclusion： This optimized process was simple with high yield, it could provide experimental basis for large-scale production of fresh R. glutinosa formula granule.

关 键 词：鲜地黄配方颗粒 成型工艺 辅料 

分 类 号：R283.6[医药卫生—中药学]