檀香不同萃取物对豚鼠离体肠平滑肌收缩的影响  

Effect of the Different Extracts from Santalum album on Isolated Ileum Smooth Muscle in Guinea Pig

作　　者：刘红艳[1,2] 郭建生[1,2,3] 王小娟[4] 陈君[1,2] 张猛[1,2] 聂子文[1,2] 

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]湖南省教育厅中药现代化研究重点实验室,长沙410208 [3]国家中医药管理局药性与药效研究三级实验室,长沙410208 [4]湖南中医药大学附属第一医院,长沙410208

出　　处：《中国实验方剂学杂志》2012年第17期175-178,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部973资助项目(2007CB512603);国家重点基础研究发展计划项目(2007CB512600);湖南省科技计划项目(2007WK3033);湖南省中药重点学科

摘　　要：目的:观察檀香不同萃取物对豚鼠离体回肠平滑肌收缩的影响,探讨其作用机制。方法:利用BL-420F生物机能实验系统,在HW-400S恒温平滑肌浴槽中,37℃下观察檀香不同萃取物对豚鼠离体回肠运动功能的影响。结果:檀香水提液乙醚萃取物、檀香水提液乙酸乙酯萃取物、檀香醇提液乙醚萃取物、檀香醇提液乙酸乙酯萃取物对豚鼠离体肠自主运动有抑制作用(P<0.01),表现为振幅减低;檀香水提液乙醚萃取物、檀香水提液乙酸乙酯萃取物、檀香醇提液石油醚萃取物、檀香醇提液乙醚萃取物、檀香醇提液乙酸乙酯萃取物对乙酰胆碱(Ach)造成的豚鼠离体肠痉挛状态有拮抗作用(P<0.01),表现为振幅减低;檀香水提液乙酸乙酯萃取物对阿托品造成的松弛状态有明显的协同作用(P<0.01),表现为振幅减低。结论:檀香不同萃取物对豚鼠离体肠平滑肌有抑制作用。Objective： To observe different extracts from Santalum album on isolated smooth muscle contraction. Method： Using BL-420F biological function experimental system and the HW-400S constant temperature smooth muscle bath isolated smooth muscle contraction was observed. Result： Water extraction liquid ethyl ether extract of S. album, water extraction liquid ethyl acetate extract of S. album, ethanol-extraction liquid ethyl ether extract of S. album, ethanol-extraction liquid ethyl acetate extract of S. album had inhibitory effect （P 〈 0.01 ）. Water extraction liquid ethyl ether extract of S. album, water extraction liquid ethyl acetate extract of S. album, ethanol-extraction liquid petroleum ether extract of S. album, ethanol-extraction liquid ethyl ether extract of S. album, ethanol-extraction liquid ethyl acetate extract of S. album from had a antagonist function （P 〈 0.01）. Water extraction liquid ethyl acetate extract of S. album, have obvious synergy on the flabby condition caused by atropine （P 〈 0.01 ）. Conclusion： Different extracts of S. album possess the inhibition on isolated intestinal smooth muscle.

关 键 词：檀香 萃取物 豚鼠离体肠 乙酰胆碱 阿托品 

分 类 号：R285.5[医药卫生—中药学]