加减补肺汤对慢性阻塞性肺病大鼠血管内皮功能的影响  

Effect of Jiajian Bufei Decoction on Content of ET and NO in Blood Plasma of Rats Model which Have Chronic Obstructive Pulmonary Disease

作　　者：李逊[1] 

机构地区：[1]遵义医学院第一附属医院,贵州遵义563003

出　　处：《中国实验方剂学杂志》2012年第17期254-256,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察加减补肺汤对慢性阻塞性肺病(COPD)肺气虚证大鼠血浆中内皮素(ET)及一氧化氮(NO)含量,探讨其作用机制。方法:Wistar大鼠随机分出正常组20只,其余80只采用烟熏复合木瓜蛋白酶雾化吸入法造模。将造模成功的大鼠分为模型组、加减补肺汤高、低剂量组(20,10 g.kg-1)、桂龙咳喘宁组(1.125 g.kg-1);正常组和模型组(0.9%氯化钠溶液10 mL.kg-1);5组均于停止烟熏当天开始灌胃,连续15 d,用放免法测定血浆ET,NO含量,并进行组间比较。结果:与模型组比较,各治疗用药组大鼠血浆ET含量降低、NO含量升高(P<0.05),加减补肺汤高剂量组血浆ET含量明显降低(178.98±4.86)ng.L-1,P<0.05;NO显著升高(37.03±0.83)μmol.L-1,P<0.05。结论:加减补肺汤能显著提高血浆NO含量,降低ET含量,调节血管内皮功能,在一定程度上控制慢性炎症反应,延缓肺动脉高压的形成。Objective： To observe the effect of Jiajian Bufei decoction on plasma endothelin （ET） and nitric oxide （NO） in rats which have chronic obstructive pulmonary disease （COPD） and traditional Chinese medicine （TCM） syndrome such as ＇Lung deficiency＇. Method： The rats were divided randomly into groups and were given the medicine. Blood was detected for the contents of plasma endothelin-1 （ET） and nitric oxide （NO） and comparisons were made between the groups. Result： The NO level in the large dosage group was markedly higher than that in the pathology control group. ET level in all treatment groups were both markedly lower than that in the pathology control group. Conclusion： Jiajian Bufei decoction can raise the NO and reducing the content of ET in blood plasma. Jiajian Bufei decoction can regulate the balance of ET and NO, thus prent and treat COPD.

关 键 词：加减补肺汤 肺气虚证 慢性阻塞性肺病 内皮素 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]