温肾开郁通痹汤治疗心肾阳虚型胸痹心痛  

Observation of Wenshen Kaiyu Tongbi Tang on Chest Stuffiness and Pain with Heart-kidney Yang Deficiency

作　　者：高征[1] 刘银伟[2] 张翠月[2] 

机构地区：[1]河南省南阳医学高等专科学校中医系,河南南阳473061 [2]河南省南阳理工学院张仲景国医学院,河南南阳473004

出　　处：《中国实验方剂学杂志》2012年第17期264-267,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨温肾开郁通痹汤治疗心肾阳虚型胸痹心痛的临床疗效及安全性。方法:采取前瞻性研究法将78例心肾阳虚型患者随机按数字法分为治疗组、对照组。治疗组41例,以自拟温肾开郁通痹汤为主加减治疗;对照组37例,口服活血化瘀中药。4周为l个疗程。观察、研究两组治疗前后的症状、心绞痛疗效、心电图、心功能、总疗效及不良反应等。结果:治疗组患者心绞痛的显效率、总有效率分别为68.3%,97.6%,对照组分别为45.9%,75.7%;治疗组患者心电图疗效的显效率、总有效率分别为63.4%,95.1%,对照组分别为37.8%,73.0%(组间比较,均P<0.05);治疗组患者中医证候改善的显效率、总有效率分别为68.3%,97.6%,对照组分别为45.9%,75.7%(组间比较,均P<0.05)。结论:以温肾开郁通痹汤治疗心肾阳虚型胸痹心痛疗效显著,安全可靠,优于对照组。Objective： To observe the clinical effect and the safety of Wenshen Kaiyu Tongbi Tang （WSKYTBT） on chest stuffiness and pain with heart-kidney yang deficiency. Method： Using prospective method, 78 patients with chest stuffiness and pain with heart-kidney yang deficiency were divided into two groups randomly. The treatment group of 41 patients was given modified self-designed WSKYTBT, and the control group of 37 patients was given Chinese herbs of Huoxue Huayu. The period of treatment was 4 weeks. Items such as symptoms, angina attack, electrocardiogram, cardiac function, adverse reactions were examined before treatment and after treatment. Result： In the treatment group significant efficiency rate and total efficacy rate of clinical symptom of angina peetoris was 68.3%, 97.6%, in the control group they were 45.9%, 75.7% （P 〈0.05）. In the treatment group significant efficiency rate and total efficacy rate of ECG were 63.4% , 95.1% , while in the control group they were 37.8% and 73.0% （P 〈 0. 05）. On the aspect of the effect on syndrome, significant efficiency rate and total efficacy rate were 68.3% and 97.6% in the treatment group, whle 45.9% and 75.7% in the control group （P 〈 0. 05）. Conclusion ： WSKYTBT can effectively improve the clinical symptoms of the patients with chest stuffiness and pain with heart-kidney yang deficiency, and it is safe and reliable as well.

关 键 词：温肾开郁通痹汤 心肾阳虚型胸痹心痛 临床研究 

分 类 号：R287[医药卫生—中药学]