近红外光谱技术在激光热疗监测中的应用研究  

Research on the Application of Near Infrared Spectroscopy Technology for Monitoring in Laser Thermotherapy

作　　者：张华[1,2] 花国然[2] 钱爱平[1] 钱志余[3] 

机构地区：[1]南通大学杏林学院,江苏南通226019 [2]南通大学机械工程学院,江苏南通226019 [3]南京航空航天大学生物医学工程系,江苏南京210016

出　　处：《应用激光》2012年第4期314-317,共4页Applied Laser

基　　金：江苏省自然科学基金资助项目(项目编号:BK2008184);南通大学杏林学院科研基金资助项目(项目编号:2010K128)

摘　　要：针对激光热疗中生物病变组织光学参数随温度变化的特点,将近红外光谱技术应用于激光诱导肿瘤间质热疗疗效监测,在线检测激光作用后生物病变组织的温度与光学参数的变化趋势,以此来对疗效进行评估。基于监测原理分析,设计实验系统,以肝癌小鼠皮下移植瘤为实验对象,研究不同激光功率和作用时间下,生物病变组织约化散射系数和温度的变化,并利用核磁共振成像技术对移植瘤术前、术后的影像进行对比。实验结果表明:病变组织的约化散射系数在激光热疗过程中呈上升趋势,起始阶段上升较快,达到一定数值后趋于稳定,整体变化趋势与温度变化趋势比较吻合,核磁影像对比也证实了治疗效果。因此,通过近红外光谱技术监测激光热疗中病变组织约化散射系数的变化可有助于指导临床激光热疗。In view of the optical parameters of biological lesions varies with temperature during laser thermotherapy, near infrared spectroscopy technology （NIRST） was used to monitor the efficacy of laser induced interstitial thermotherapy （LITr） with the method of testing the trend of temperature and optical parameters of biological lesions. Based on the analysis of the monitoring principle, an experimental system has been designed. The subcutaneous implanted rat liver cancers were used for LITY experiments. Under different laser power and duration of action, the reduced scattering coefficient and temperature of the liver cancer were recorded. The images of the liver cancer have been compared with magnetic resonance imaging （MRI）. The experimental results show that the reduced scattering coefficients of the diseased tissue has an upward trend during LITr, it increases quickly at beginning and gradually reached the stable state. The overall trends of reduced scattering coefficients are consistent with the temperature. The therapeutic effects are confirmed with MRI. Thus, NIRST is help to guide LITr with monitoring the changes of the reduced scattering coefficients.

关 键 词：激光生物学 激光热疗 近红外光谱 光学参数 

分 类 号：Q631[生物学—生物物理学]