白癜风患者血清巨噬细胞移动抑制因子和肿瘤坏死因子α的表达  

Detection of macrophage migration inhibition factor and tumor necrosis factor-α in the sera of patients with vitiligo

作　　者：肖汉龙[1] 陶娟[2] 刘辉峰[2] 安湘杰[2] 杨柳[2] 涂亚庭[2] 

机构地区：[1]武警湖北省总队医院,武汉430061 [2]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《中华皮肤科杂志》2012年第9期673-674,共2页Chinese Journal of Dermatology

基　　金：国家自然科学基金（30872272）

摘　　要：目的探讨白癜风患者血清中巨噬细胞移动抑制因子（MIF）和肿瘤坏死因子α（TNF-α）水平的变化及临床意义。方法酶联免疫吸附试验和放射免疫法检测66例白癜风患者和30例健康对照血清MIF和TNF-α的表达。结果寻常型白癜风患者组和健康对照组血清MIF水平分别为（9．56±1．65）μg/L和（5．18＋0．81）μg/L，TNF-α水平分别为（2．38±0．37）μg/L和（1．78±0．21）μg／L，寻常型白癜风患者组均显著高于健康对照组（P值均〈0．01）。寻常型白癜风患者血清MIF和TNF-α水平呈正相关（r=0．89，P〈0．05）。节段型白癜风患者组血清MIF和TNF-α水平与健康对照组比较，差异均无统计学意义（P〉0．05）。进展期白癜风患者血清MIF水平显著高于稳定期（P〈0．01）。结论MIF和TNF-α可能在白癜风的发病机制中起一定作用。MIF与寻常型白癜风的活动性可能有关。Objective To determine the serum levels of macrophage migration inhibition factor （MIF） and tumor necrosis factor-or （TNF-α） in patients with vitiligo, and to investigate their clinical significance. Methods The serum concentrations of MIF and TNF-α were determined by enzyme linked immunosorbent assay （ELISA） and radioimmunoassay respectively in 66 patients with vitiligo and 30 healthy controls. Results The patients with vitiligo vulgaris showed a significant higher serum level of MIF and TNF-α compared with the healthy controls （（9.56 ± 1.65） vs.（5.18 ± 0.81） μg/L, （2.38 ± 0.37） vs.（1.78 ± 0.21） μg/L, both P 〈 0.01）. There was a positive correlation between the serum level of MIF and TNF-α （r = 0.89, P 〈 0.05）. No statistical difference was observed in the serum levels of MIF or TNF-α between the healthy controls and patients with segmental vitiligo （both P 〉 0.05）. The serum level of MIF was significantly higher in patients with progressive vitiligo than in those with stable vitiligo （P 〈 0.01 ）. Conclusions MIF and TNF-α might play a certain role in the pathogenesis of vitiligo, and MIF may be related to the activity of vitiligo vulgaris.

关 键 词：巨噬细胞移动抑制因子 寻常型白癜风 肿瘤坏死因子Α 患者 血清 TNF-Α 健康对照组 酶联免疫吸附试验 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]