胎膜早破胎膜中白细胞介素18的表达及其临床意义  

Expression and clinical significance of interleukin-18 in premature rupture of membrane

作　　者：张茗[1] 

机构地区：[1]大连市妇产医院产科五病房,辽宁大连116033

出　　处：《大连医科大学学报》2012年第4期352-354,共3页Journal of Dalian Medical University

摘　　要：[目的]探讨白细胞介素18(interleukin-18,IL-18)作为诊断胎膜早破(premature rupture of membrane,PROM)生物学标志的可能性。[方法]应用免疫组织化学SP法检测42例PROM患者及28例正常产孕妇胎膜的IL-18表达,并加以比较。[结果]PROM胎膜中IL-18表达明显高于正常胎膜组织(P<0.05)。合并亚临床绒毛膜羊膜炎PROM胎膜组织的IL-18表达明显高于不合并绒毛膜羊膜炎组织(P<0.05)。IL-18的表达与胎膜早破时间无明显相关性。[结论]IL-18作为一种细胞因子有可能成为PROM的预测性指标。[Objective] To detect expresson of interleukin-18（IL-18） in the tissne with premature rupture of fetal membrane（PROM） and clinical pathological significance of the expression.[Methods] The expression of IL-18 was detected in 42 tissues with premature rupture of fetal membranes and 28 normal of fetal membrane tissues without by immunohistochemistry.[Results] The expression of IL-18 was significantly higher in premature rupture of membrane than that in normal（P〈0.05）,and the expression of the tissues in PROM with sub-clinical chorioamonitis was significantly higher than that without（P〈0.05）.The correlativity between the expression of IL-8 and the time of PROM was not clear（P〈0.05）.[Conclusions] The IL-18 could become a predictable index of PROM.

关 键 词：白细胞介素18 胎膜早破 免疫组织化学 

分 类 号：R714.433[医药卫生—妇产科学]