血清胱抑素C测定对妊娠期早期肾损害诊断的临床意义  

Diagnosis valve of Cystatin C to the early renal damage of pregnant women

作　　者：孙芹敏[1] 吕璘琳[1] 

机构地区：[1]大连医科大学附属第一医院检验科,辽宁大连116011

出　　处：《大连医科大学学报》2012年第4期397-399,共3页Journal of Dalian Medical University

摘　　要：[目的]探讨血清胱抑素C(CysC)测定对妊娠期妇女早期肾损害诊断的临床意义。[方法]分别检测35例正常晚期妊娠妇女、24例妊高症妇女和40例健康对照未孕女性的血清CysC、尿素氮(BUN)、肌酐(CR)、尿酸(UA)及尿微量白蛋白(MA)。[结果]血清CysC水平在正常晚期妊娠组(1.29±0.16)mg/L和妊高症组(1.82±0.46)mg/L均明显高于健康对照组(0.73±0.11)mg/L,差异有显著性意义(P<0.05),且妊高症组与正常晚期妊娠组比较差异也具有显著性意义(P<0.05)。尿MA水平妊高症组(3.01±1.91)mg/dL显著高于健康对照组(1.66±1.37)mg/dL及正常晚期妊娠组(1.09±1.28)mg/dL(P<0.05)。BUN、CR及UA水平在3组间均无显著差别(P>0.05)。[结论]血清CysC水平的升高可能对诊断妊娠期高血压并发早期肾损害具有一定意义。[Objective] To evalute the valve of CysC to diagnose the early renal damage of pregnant women.[Methods] The CysC,urea（BUN）,creatinine（CR）,uric acid（UA） and microalbuminuria（MA） were detected in 35 normal late pregnancy women,24 pregnancy-induced hypertension syndrome women and 40 healthy（normal control group）.[Results] The CysC levels of normal late pregnancy group（1.29±0.16） mg/L and pregnancy-induced hypertension syndrome group（1.82±0.46）mg/L were significantly higher than that of normal control group（0.73±0.11） mg/L（P〈0.05）.And pregnancy-induced hypertension syndrome group was significantly higher than that of normal late pregnancy group（P〈0.05）.The levels of MA had no statistical difference between normal late pregnancy group（1.09±1.28）mg/dL and normal control group（1.66±1.37）mg/dL（P〈0.05）,while the level of pregnancy-induced hypertension syndrome group（3.01±1.91）mg/dL was significantly higher than both of them（P〈0.05）.There is no statistical difference of BUN,CR,UA among three groups（P〉0.05）.[Conclusion] The increase of serum CysC level might be helpful to diagnose pregnancy early renal damage.

关 键 词：胱抑素C 晚期妊娠 妊高症 尿微量白蛋白 

分 类 号：R446.6[医药卫生—诊断学]