生长激素对高龄卵巢储备功能低下患者IVF-ET治疗结局的影响  

The Effect of Growth Hormone on the IVF Outcome of the Patients of Advanced Age With Decreased Ovarian Reserve

作　　者：宋慧玲[1,2] 郭艺红[1] 

机构地区：[1]郑州大学第一附属医院生殖医学中心,郑州450052 [2]开封市妇幼保健院,河南开封475002

出　　处：《河南职工医学院学报》2012年第4期430-433,共4页Journal of Henan Medical College For Staff and Workers

摘　　要：目的探讨GH对高龄卵巢储备功能低下患者在IVF-ET中是否有影响。方法自2010年1月至2011年2月在郑州大学第一附属医院生殖中心行IVF-ET的高龄(年龄≥35岁)卵巢储备功能低下的不孕患者69例,所有患者均在该中心采用普通长方案降调节。结果实验组(应用GH)39例,对照组(未用GH)30例。生长激素(GH)对年龄≥35岁的不孕症患者Gn用量(Gn支数)实验组显著低于对照组,有统计学差异(P<0.05);HCG日E2水平、获卵数实验组显著高于对照组,有统计学差异(P<0.05)。结论生长激素对高龄(年龄≥35岁)卵巢储备功能低下患者的卵巢反应及IVF-ET治疗结局有一定影响,可减少Gn使用量,提高HCG日的E2水平,增加获卵数。Objective To discuss whether growth hormone （GH） positively affect the IVF outcome of advanced age （equal to or above 35 years old） patients with decreased ovarian reserve. Methods Sixty-nine infertile patients with decreased ovarian reserve, admitted to the Reproductive Medical Centre of the first affiliated hospital of zhengzhou university from January, 2010 to February, 2011, were en-rolled into our study. All these patients in this study had been down regulated according to the conven- tional long protocol in our centre. Ovarian response and outcome of IVF were observed in both groups. 69 patients equal to or above 35 years old divided into two groups by having used GH in their cycles or not. Patients received GH were taken as the experimental group with 39 cases, while those were not taken as the control group with 30 cases. Results Effect of GH on patients equals to or more than 35 years old with diminished ovarian reserve ： the dosage of Gn was significantly lower （P 〈 0.05 ） , and its duration was shorter in the experimental group than those in the control groups. The level of estradiol and the num- ber of retrieved ovum were significantly higher（P 〈0.05） in the control groups. Conclusion GH may diminish the dosage of Gn, elevate the level of estradiol on the day of HCG injection and increase the number of ovum for the patients equal to or more than 35 years old with decreased ovarian reserve.

关 键 词：生长激素 卵巢储备功能低下 高龄 IVF-ET治疗结局 

分 类 号：R711.6[医药卫生—妇产科学]