种植窗口期子宫内膜中MMP-9、TIMP-1及ICAM-1的表达与体外受精-胚胎移植妊娠结局的关系  

The relationship between expression of MMP-9/TIMP-1 and ICAM-1 in the implantation window and the outcome of In Vitro Fertilization and Embryo Transfer

作　　者：盛敏[1] 任春娥[1] 韩海艳[2] 乔鹏云[2] 姜爱芳[1] 王桂丽[1] 

机构地区：[1]潍坊医学院,山东潍坊261053 [2]潍坊医学院附属医院,山东潍坊261031

出　　处：《中国卫生检验杂志》2012年第8期1827-1830,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨种植窗口期子宫内膜中MMP-9、TIMP-1和ICAM-1的表达及其与体外受精-胚胎移植妊娠结局的关系。方法:收集40例拟行IVF/ICSI-ET妇女前1周期黄体中期的子宫内膜组织,分别检测妊娠组与非妊娠组中MMP-9、TIMP-1及ICAM-1的表达。结果:与妊娠组相比,非妊娠组中MMP-9、TIMP-1及ICAM-1的表达显著降低,差异有显著性(P<0.05)。结论:种植窗口期子宫内膜中MMP-9、TIMP-1及ICAM-1表达降低,影响胚胎的着床,降低妊娠率,可作为预测IVF/ICSI-ET妊娠结局的指标之一。Objective ： To investigate the expression of MMP - 9, TIMP - 1 and ICAM - 1 in the planting window of endometrial tissue and the relationship with the pregnancy in IVF. Methods：The midluteal endometrial tissue of the first cycle from 40 women undergoing IVF/ICSI - ET were collected for detecting the expression of MMP - 9, TIMP - 1 and ICAM - 1. The women were divided into two groups, pregnancy group and non - pregnant group Re- suits ： The expression of MMP - 9, TIMP - 1 and ICAM - 1 in non - pregnant group was lower than that in pregnant group, and there was significant difference between the two groups （ P 〈 0.05 ）. Conclusion： The lower expression of MMP - 9, TIMP - 1 and ICAM - 1 in the endometrial tissue of planting window can affect the implantation of em- bryo and cause the failure of the pregnancy in IVF. So the expression of MMP - 9, TIMP - 1 and ICAM - 1 in the endometrial tissue of planting window can be used as one of the indicators of pregnancy in the IVF/ICSL - ET.

关 键 词：基质金属蛋白酶 细胞间黏附分子 种植窗口期 胚胎移植 妊娠 

分 类 号：R713.7[医药卫生—妇产科学]