心力衰竭患者B型钠尿肽及其肌钙蛋白Ⅰ和超敏C反应蛋白水平的变化  

The change of hyper-sensitive C-reactive protein,cardiac troponin Ⅰ and brain natriuretic peptide in chronic heart failure patients

作　　者：章火祥[1] 邵卫勇[1] 万晓晨[1] 

机构地区：[1]浙江医院医学检验科,杭州310013

出　　处：《中国卫生检验杂志》2012年第8期1883-1885,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:观察慢性心力衰竭(CHF)患者心肌损伤指标肌钙蛋白I(cTnI)和炎症指标超敏C反应蛋白(hs-CRP)含量变化并探讨其与CHF不同类型及B型钠尿肽(BNP)之间的关系。方法:选择经临床确诊的CHF患者160例(NYHAⅠ-Ⅳ级),健康对照者150名,无CHF的心血管患者142例。用免疫荧光定量分析法测定其全血hs-CRP和BNP水平,微粒子酶促化学发光免疫分析法测定其血清cTnI水平,并进行对比分析。结果:CHF患者组全血BNP和hs-CRP水平均显著高于无CHF的心血管患者组和健康对照组,血清cTnI值CHF患者组亦均显著高于无CHF的心血管患者组和健康对照组(P均<0.01)。且随心功能NY-HA分级的增高,全血BNP水平逐渐升高,组间差别均有统计学意义,而全血hs-CRP与血清cTnI水平随心功能NYHA分级的增高,组间差别均无统计学意义(P均>0.05),但均较健康对照组升高。结论:慢性心力衰竭疾病过程中存在着心肌损伤和炎症,表明心肌损伤和炎症是这种疾病病理生理过程的重要成分,但这种心肌损伤和炎症与心功能NYHA分级和障碍程度无关。Objective： To investigate serum levels of cardiac troponin I （ cTnI）, a marker of myocardial injury and blood concentrations of hyper- sensitive C -reactive protein（hs -CRP） , a marker of inflammatory in patients with chronic heart failure（CHF） and relationship between cTnI, hs -CRP levels and cardiac function as well as brain natriuretic peptide （BNP）. Methods： The levels of serum cTnI and blood hs - CRP, BNP concentrations in 160 CHF patients diagnosed by clinics（ NYHA I - IV ） , 142 cardiac patients without CHF and 150 healthy controls were measured by fluorescence immunoassay. Results ： The blood concentrations of hs - CRP and BNP were significantly higher in CHF group than those in cardiac patients without CHF and healthy controls. The level of serum cTnI in CHF group was also much higher than that in cardiac patients without CHF and healthy controls （P 〈 0.01 ）. Furthermore, the blood concentrations of BNP increased along with increment of CHF severity （ NYHA cardiac functional classification）, while the levels of serum eTnI and the blood concentrations of hs - CRP had no statistical difference （P 〉 0.05 ）, but they were all much higher than those in healthy controls. Conclusion ： Myocardial injury and inflammatory may play an important role in the occurrence and development of CHF, but it may have nothing to do with the increment of CHF severity （ NYHA cardiac functional classification）.

关 键 词：心力衰竭 肌钙蛋白I C反应蛋白 利钠肽 脑 

分 类 号：R541.6[医药卫生—心血管疾病]