2-氯丙酸异丙酯的合成  

Synthesis of Isopropyl 2-chloropropionate

作　　者：李勇 田青松 张文静 王玉东 

机构地区：[1]河北万全宏宇化工有限责任公司,河北张家口076271

出　　处：《河北化工》2012年第9期45-46,49,共3页Hebei Chemical Industry

摘　　要：以固体超强酸树脂为催化剂合成2-氯丙酸异丙酯,研究了催化剂的用量、反应起始原料物质的量比、反应时间、带水剂种类及用量对酯化反应的影响,确定了合成2-氯丙酸异丙酯的最佳反应条件为:n(异丙醇)∶n(环己烷)∶n(催化剂)∶n(2-氯丙酸)=5∶6.5∶0.3∶1,反应时间为2h,在此条件下,2-氯丙酸异丙酯的收率可达到95%,纯度达到99%以上。To synthesize isopropyl 2-chloropropionate with super acid resin as catalyst,and study the influences of catalyst dosage,raw material ratio,reaction time water-carrying agent varieties and dosage.The total yield was 95% and purity of the title compound was above 99% under the optimum conditions that included n（2-propanol）∶n（cyclohexane）∶n（catalyst）∶n（2-chloropropionic acid）=5∶6.5∶0.3∶1,and reaction time was 2 h.

关 键 词：2-氯丙酸 2-氯丙酸异丙酯 合成 

分 类 号：TQ450.41[化学工程—农药化工]