氟比洛芬压敏胶分散型贴剂家兔体内药动学研究  

Pharmacokinetics Study of Drug-in Adhesive Patches of Flurbiprofen in Rabbits

作　　者：李志荣[1] 王刚[1] 杜士明[1] 朱海涛[1] 陈永顺[1] 

机构地区：[1]湖北医药学院附属太和医院药学部,湖北十堰442000

出　　处：《中国药师》2012年第7期942-944,共3页China Pharmacist

摘　　要：目的:研究氟比洛芬压敏胶分散型贴剂在家兔体内的药动学。方法:12只家兔分为氟比洛芬巴布膏组与氟比洛芬压敏胶分散型贴剂组,给药后不同时间取血,用HPLC测定血药浓度,用3P97软件计算药动学参数。结果:氟比洛芬透皮贴剂在家兔体内的药动学过程符合一室模型,相同剂量的氟比洛芬巴布膏与氟比洛芬压敏胶分散型贴剂的主要药动学参数为:t_(max)分别为(5.95±0.48)和(6.11±0.45)h,C_(max)分别为(16.50±2.15)和(13.52±1.52)μg·ml^(-1),T_(1/2ka)分别为(2.50±0.42)和(2.64±0.58)h,T_(1/2ka)别为(5.76±0.37)和(6.84±1.09)h,AUC_(0-24)分别为(124.56±12.52)和(146.86±15.98)mg·h·L^(-1)。结论:自制的氟比洛芬压敏胶分散型贴剂与相应的巴布剂相比,具有更缓释、长效的作用。Objective： To explore the pharmacokineties of drug-in adhesive patches of flurbiprofen in rabbits. Method： Twelve rabbits were randomly divided into flurbiprofen eataplasm group and drug-in adhesive patches of flurbiprofen group. The concentration of flurbiprofen in the plasma of rabbits was determined by HPLC and the pharmaeokineties parameters were calculated by 3P97 soft- ware. Result： The pharmacokinetie data were fitted a one-compartment model, and the main pharmaeokinetic parameters of the two preparations were as follows： tmas of（ 5.95 ± 0.48 ） and（ 6.11 ±0.45 ） h, Cmas of （ 16.50 ±2.15 ） and（ 13.52 ±1.52） μg · ml- 1, T1/2ka of （2.50±0.42） and（2.64 ±0.58）h, T1/2ke of （5.76 ±0.37）h and（6.84 ±1.09）h,AUC0-24, of （124.56 ±2.52） and（146.86 ±15.98 ）mg · h· L-1. Conclusion： Drug-in adhesive patches of flurbiprofen exhibit promising sustained-release property.

关 键 词：氟比洛芬 压敏胶分散性贴剂 药动学 

分 类 号：R969.1[医药卫生—药理学]