氟比洛芬压敏胶分散型贴剂的制备及体外经皮渗透性考察  

Preparation and In Vitro Permeability of Flurbiprofen-loaded Drug-in Adhesive Patches

作　　者：陈永顺[1] 王刚[1] 杜士明[1] 朱海涛[1] 董永成[1] 

机构地区：[1]湖北医药学院附属太和医院药学部,湖北十堰442000

出　　处：《中国药师》2012年第7期959-962,共4页China Pharmacist

摘　　要：目的:研制氟比洛芬压敏胶分散型贴剂并考察其体外经皮渗透性。方法:将氟比洛芬及各种促渗剂直接溶于压敏胶中制备压敏胶分散性贴剂,采用卧式双室扩散池,研究其体外经皮渗透行为。结果:由Duro-Tak 87-9301型压敏胶制备的贴刺具有较好的稳态渗透速率。5%氯酮与10%豆蔻酸异丙酯合用对氟比洛芬促渗效果明显,经皮渗透速率为(3.35±0.53)μg·cm^(-2)·h^(-1),促渗倍率达2.68倍。贴剂中氟比洛芬的含量由5%增加到10%,经皮渗透速率明显增大,含量增加到15%和20%时,渗透速率无明显变化。结论:所得处方中各因素的组合有利于氟比洛芬的经皮吸收。Objective： To prepare flurbiprofen-loaded drug-in adhesive patches and evaluate the in vitro transdermal permeability. Method： Flurbiprofen-loaded drug-in adhesive patches were prepared by dissolving flurbiprofen and different enhancers with the pressure sensitive adhesive. Permeation characteristics of flurbiprofen from the patches were evaluated using two-compartment horizontal dif- fusion cells. Result： Duro-Tak 87-9301 adhesive showed promising stable penetration rate. The patches with 5% Azone and 10% isopropyl myristate as the enhancer showed the optimal permeability with the mean permeation rate of（ 3, 35 ±0.53 ） μg·cm-2 ·h -1 and enhancement ratio of 2.68-fald. The permeation rate was increased significantly with the increase of flurbiprofen content from 5% to 10%, and kept stable with the flurbiprofen content between 10% and 20%. Conclusion： The preparation was benefit for percutaneous absorption of flurbiprofen.

关 键 词：氟比洛芬 压敏胶分散性贴剂 透皮促渗剂 经皮渗透性 体外 

分 类 号：R945[医药卫生—微生物与生化药学]