白藜芦醇抗喘活性及机制研究  

Effect and mechanism of resveratrol on antiasthmatic activity

作　　者：何冰[1] 王经韵[2] 郑宇翔[1] 徐浚超[1] 陈小夏[1] 

机构地区：[1]广东药学院药科学院,广东广州510006 [2]广东省人民医院国家临床药物试验机构办公室,广东广州510080

出　　处：《广东药学院学报》2012年第4期423-426,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的观察白藜芦醇对豚鼠在体和离体气管平滑肌的松弛作用,并探讨其作用机制。方法建立豚鼠哮喘模型,采用豚鼠离体气管条法,观察白藜芦醇对豚鼠气管平滑肌的舒张作用。结果白藜芦醇可显著延长豚鼠引喘潜伏期,对乙酰胆碱、氯化钾、组胺诱发的气管收缩有明显的舒张作用;吲哚美辛和格列本脲预孵育明显减少了白藜芦醇对离体气管条的舒张作用。结论白藜芦醇具有平喘和明显的舒张气管平滑肌的作用,其机制可能与钙拮抗、促进前列腺素合成和激活ATP敏感性钾离子通道有关。Objective To study the relaxant effect of resveratrol（Res） in vivo and in vitro on guinea-pig tracheal smooth muscle,and its potential mechanism.Methods Tracheal strips were isolated and the model of asthmatic guinea-pig was established.The function of Res on antiasthmatic effect was detected.Results Res obviously prolonged the latency time of asphyxiation collapse induced by histamine（His） and acetyl-choline（Ach） in guinea-pigs,and abrogated the tension of tracheal smooth muscle of precontraction induced by Ach,KCl and His.The effect of Res on relaxation was attenuated by pretreatment with indomethacin and glibenclamide.Conclusion Res exhibit a significant antiasthmatic and relaxing effect on tracheal smooth muscle of guinea-pig.The mechanism of Res may be related to antagonizing of calcium channel,elevating prostaglandin levels,and opening ATP-sensitive potassium channel.

关 键 词：白藜芦醇 平喘作用 离体气管平滑肌 钙通道 钾通道 

分 类 号：R285.5[医药卫生—中药学]