PK-PD模型的研究进展  

The research progresses of the PK-PD modeling

作　　者：曾洁[1] 王素军[1] 杨本坤[1] 莫李立[1] 

机构地区：[1]广东药学院临床药学系,广东广州510006

出　　处：《广东药学院学报》2012年第4期461-464,F0003,共5页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金(81073141);广东省自然科学基金(9152402301000007);广东省医学科学技术研究基金(A2009317)

摘　　要：PK-PD模型把剂量-浓度、浓度-效应的关系结合在一起进行研究,更有助于描述、预测量效关系。PK-PD模型可分为4类:直接连接与间接连接、直接反应与间接反应、软连接与硬连接及时间依赖和非时间依赖模型。PK-PD模型已广泛用于药物临床前及临床的各方面研究,如制定给药剂量、药物安全性及有效性的评价。本文对PK-PD模型分类及其应用进行综述。The pharmacokinetic-pharmacodynamic（PK-PD） model,linking dose-concentration relationship and concentration-effect relationship,facilitates the description and prediction of the time course of drug effects resulting from a certain dosing regimen.Four types of PK-PD models have been distinguished,including direct-link versus indirect-link model,direct-response versus indirect-response model,soft-link versus hard-link model and time-variant versus time-invariant model.PK-PD model has been widely applied in preclinical and clinical drug development,such as formulation of dosage,the estimate of drug safety and efficacy.In the present paper,the classification and research progress of the PK-PD model are reviewed.

关 键 词：PK-PD模型 分类 应用 

分 类 号：R969.1[医药卫生—药理学]