微小RNA与缺血性脑损伤  

MicroRNA and Cerebral Ischemia

作　　者：张煜[1] 郭军[1] 

机构地区：[1]南京医科大学基础医学实验教学中心,南京210029

出　　处：《中国医学科学院学报》2012年第4期418-421,共4页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81170714);江苏省"六大人才高峰"高层次人才项目~~

摘　　要：微小RNA(miRNA)是一类高度保守的单链RNA,在机体发育代谢过程中发挥重要调节作用。中枢神经系统存在大量的miRNA,不仅与神经细胞的发育、分化和生理功能密切相关,在脑缺血后神经病变和功能失调中也发挥重要的调节作用。特定miRNA能通过自身水平变化影响缺血后其靶基因的表达,参与神经细胞保护机制以及凋亡再生机制的调控。充分了解脑内特异性miRNA的功能和调控机制,有助于从基因水平上为缺血性脑损伤的预防、诊断和治疗提供新的策略。MicroRNAs （miRNAs） are a class of highly conserved single-stranded RNA molecules that modulate gene translation. By targeting the mRNA of protein- coding genes, miRNAs play a critical role in neuronal differentiation, cell proliferation, apoptosis and metabolism. There are a lot of miRNAs in central nervous system, which are not only closely linked to development, differentiation and function of nerve cells, also play an important role in nerve lesions and dysfunction after cerebral ischemia. Specific miRNA through their own changes affect their target gene expression levels after focal cerebral ischemia, involving in the protec- tion against apoptosis in neurons and regeneration after cerebral ischemia. A full understanding of the specific microRNA function and its underlying mechanism in the brain can provide a new strategy for the prevention, di- agnosis, and treatment of ischemic cerebral injury at gene level.

关 键 词：脑缺血 微小RNA 功能 

分 类 号：Q52[生物学—生物化学]