砷剂治疗某些皮肤病的研究进展  

Arsenic in the treatment of some kinds of dermatoses

作　　者：栾莉[1] 张振颖[1] 刘晓明[1] 

机构地区：[1]大连医科大学附属第一医院皮肤科,116011

出　　处：《国际皮肤性病学杂志》2012年第5期291-293,共3页International Journal of Dermatology and Venereology

摘　　要：砷剂在银屑病、皮肤T细胞淋巴瘤和黑素瘤等方面具有一定的药理活性，砷剂在一定浓度下可抑制细胞增殖、诱导细胞凋亡，并促进皮肤肿瘤消退，具有一定的应用前景。砷剂同时具有细胞毒性，可积蓄中毒，累及身体各组织器官，根据流行病学研究，其可诱变致癌。砷有两面性，需要进行更多的基础实验和临床试验研究，选择最佳的治疗浓度，以减少毒副作用。同时如能根据影响砷毒副作用的基因多态性，采用个体化给药，使其更好地发挥治疗作用而降低不良反应的风险，成为某些皮肤病的治疗手段之一。Arsenic has shown some medicinal properties in psoriasis, cutaneous T cell lymphoma, melanoma, and so on. On the one hand, arsenic at certain concentrations can suppress cell growth, induce cell apoptosis and cause the regression of skin neoplasms. On the other hand, arsenic has cytotoxicity, and can be accumulated in and induce damages to various organs of the human body. Epidemiological studies have shown that arsenic may be carcinogenic. Therefore, more basic research and clinical trials are warranted to optimize the therapeutic close of arsenic so as to minimize its side effects. Individualized administration of arsenic based on gene polymorphisms associated with its side effects may enable arsenic to be an effective treatment option for some kinds of skin disorders with minimal risk.

关 键 词：砷剂 银屑病 淋巴瘤 T细胞 皮肤 黑色素瘤 

分 类 号：R751[医药卫生—皮肤病学与性病学]