提高氨基酮戊酸透皮能力的方法  

Methods to improve transdermal delivery of aminolevulinic acid

作　　者：石磊 王秀丽 王宏伟 

机构地区：[1]上海市皮肤病医院,200050

出　　处：《国际皮肤性病学杂志》2012年第5期294-297,共4页International Journal of Dermatology and Venereology

基　　金：上海市自然科学基金（11ZR1432800）

摘　　要：氨基酮戊酸光动力治疗在皮肤科领域应用广泛，由于氨基酮戊酸透皮能力低，限制氨基酮戊酸光动力治疗的疗效。氨基酮戊酸衍生物，微针、激光、离子导入和运输载体技术相继被应用于提高氨基酮戊酸的透皮能力，并且取得了一定的效果。它们可通过不同的机制提高氨基酮戊酸透皮的深度和透皮的量，使氨基酮戊酸光动力治疗能更有效地应用于皮肤科领域。Aminolevulinic acid-based photodynamic therapy （ALA-PDT） has been extensively applied in dermatology. However, the low permeability of ALA across intact skin has limited the efficacy of ALA-PDT. To enhaee the percutaneous penetration of ALA, esterified derivatives, microneedles, laser, iontophoresis, delivery vehicles have been used in succession, and some achievements have been made. These methods can increase the transdermal delivery of ALA in terms of depth and quantity by different mechanisms, and indirectly promote the efficacy of ALA-PDT in dermatoses.

关 键 词：光化学疗法 氨基酮戊酸 透皮 运输载体 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]