芳香烃受体参与自身免疫性皮肤病发病机制的研究进展  

Aryl hydrocarbon receptor participates in the development of autoimmune dermatoses： an update on mechanisms

作　　者：王筱雯[1] 李春英[1] 高天文[1] 

机构地区：[1]第四军医大学西京医院皮肤科,西安710032

出　　处：《国际皮肤性病学杂志》2012年第5期304-306,共3页International Journal of Dermatology and Venereology

摘　　要：芳香烃受体是一种胞质转录因子，参与免疫应答、小分子物质代谢、内分泌稳态及黑素合成等多种生物学过程。近年来研究发现，芳香烃受体能够介导外源性小分子化学物质干扰免疫系统，导致机体产生变态反应和自身免疫反应，其在自身免疫性皮肤病的发生发展中也发挥着作用。概述芳香烃受体的信号通路、免疫功能及其与自身免疫性皮肤病相关性的研究进展，进一步了解自身免疫性皮肤病的发病机制，为疾病的免疫治疗提供新思路。Aryl hydrocarbon receptor, a cytosolic transcription factor, takes part in many biological processes including immune response, endocrine secretion, melanin synthesis and metabolism of low-molecular- weight molecules. Recent research has confirmed that aryl hydrocarbon receptor can interfere with immune system and result in allergic reaction and autoimmune response via interacting with low-molecular-weight chemicals. Also, aryl hydrocarbon receptor plays an important role in the development of autoimmune dermatoses. The authors review aryl hydrocarbon receptor signaling pathway, immunological functions and its association with autoimmune dermatoses, which may help to understand the pathogenesis of autoimmune dermatoses, and offer new ideas for immunotherapy of diseases.

关 键 词：自身免疫性皮肤病 受体 芳香烃 TH17细胞 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]