急性冠状动脉综合征患者Fractalkine水平的研究  

Changes of circulating fractalkine in patients with acute coronary syndroms

作　　者：姚康[1] 陆浩[1] 张春瑜[1] 吴彦[2] 葛雷[1] 钱菊英[1] 邹云增[1] 葛均波[1] 

机构地区：[1]复旦大学附属中山医院心内科,上海200032 [2]解放军第85医院心内科

出　　处：《中国介入心脏病学杂志》2012年第4期181-184,共4页Chinese Journal of Interventional Cardiology

基　　金：国家自然科学基金资助项目资助(30900600);高等学校博士点新教师基金资助(20090071120027)

摘　　要：目的最近研究发现新型趋化因子Fractalkine与动脉粥样硬化的炎症免疫发病有关,我们对临床各种急性冠状动脉综合征患者循环可溶性Fractalkine(sFractalkine)水平进行了观察。方法选取急性冠状动脉综合征患者56例,其中急性心肌梗死(AMI)20例,不稳定心绞痛(UP)36例,同时以25例稳定性心绞痛(SAP)作为对照,所有患者均经冠状动脉造影证实;其中不稳定心绞痛患者行血管内超声检查,对斑块性质做出判定;ELIZA法检测外周血sFractalkine及高敏C反应蛋白(hs-CRP)水平。结果 AMI组sFractalkine水平(900.9±66.6)pg/ml显著高于UP(F=4.21,P=0.0008)及SAP组(F=4.85,P=0.0006),血管内超声确定有斑块破裂的UP患者sFractalkine水平(717.8±49.1)pg/ml显著高于UP组无斑块破裂者(610.9±34.8)pg/ml(F=2.21,P=0.03),sFractalkine水平与hs-CRP呈显著正相关(r=0.329,P=0.003)。结论 sFractalkine可能与动脉粥样硬化的炎症免疫发病,尤其是在斑块破裂过程中起着重要作用。Objective The recently discovered chemokine Fractalkine and its receptor CX3CR1 was found to play an important role in the inflamed atherosclerotic lesions. We evaluated the changes of circulating Fractalkine in patients with acute coronary syndroms. Methods The study consisted of 36 patients with unstable angina pectoris （UP） and 20 patients with acute myocardial infarction （AMI）. Another 25 stable angina pectoris （SAP） patients were regarded as control. The UP patients underwent intravaseular ultrasound （IVUS） examination to study the characteristics of culprit lesions, which revealed that the number of patients with and without plaque rupture at the culprit site was 20 （rupture group） and 16 （non-rupture group） , respectively. Plasma levels of soluble Fractalkine （sFKN） was measured by enzymelinked immunosorbent assay. Results The plasma levels of sFKN were significantly increased in AMI patients （900. 9 ±66. 6） pg/ml. Compared with SAP （555.3 ±36. 3 ） pg/ml, P = 0. 01 and UP patients without plaque rupture （610. 9 ±34. 8 ） pg/ml, P = 0. 03, sFKN were significantly higher in UP patients with plaque rupture （717.8 ±49. 1 ） pg/ml. Circulating FKN level positively correlated with serum hs-CRP （r = O. 329, P = 0. 003 ） level. Conclusions Our primary study suggested that increases in the FKN level might contribute to coronary plaque rupture and be a useful marker for detecting unstable coronary disease.

关 键 词：炎症趋化因子类 急性冠状动脉综合征 动脉粥样硬化 

分 类 号：R392.11[医药卫生—免疫学]