大黄中一个新的蒽醌苷(英文)  

A new anthraquinone glycoside from the root of Rheum officinale Baill.

作　　者：夏正祥[1] 唐中艳 安叡[1] 陈烨 张艺竹[1] 王新宏[1] 

机构地区：[1]上海中医药大学中药学院,上海201203 [2]上海市闵行区医疗急救中心,上海201100

出　　处：《药学学报》2012年第9期1183-1186,共4页Acta Pharmaceutica Sinica

基　　金：Project supported by Research and Innovation Key Projects for the 2011 Shanghai Municipal Education Commission(11ZZ110);Doctoral Program of Higher Specialized Research Fund(20093107110011);National Natural Science Foundation of China(81202863)

摘　　要：为了对药用大黄的根进行化学成分研究,采用硅胶、凝胶、反相等柱色谱和高效液相色谱方法分离和纯化化合物,根据理化性质和波谱方法鉴定化合物结构。从大黄的乙醇提取物中分离得到了1个新的和1个已知的蒽醌苷类化合物。此外,还测试了化合物对肝癌细胞的细胞毒活性。A new and a known anthraquinone glycosides were isolated from the ethanol extract of the roots of Rheum officinale Baill. The extract was purified by various chromatographies, such as silica gel, Sephadex LH-20, RP-C18 column chromatography and HPLC. Two compounds were identified by the spectroscopic techniques of NMR, MS, and chemical method. In addition, they were tested for their cytotoxic effects against HepG2 cell. Unfortunately, they showed no or weak activity.

关 键 词：大黄属 大黄 蒽醌苷类 

分 类 号：R284[医药卫生—中药学]