职业性锰接触对工人尿锌水平的影响  

Effect of occupational manganese exposure on urinary zinc levels of workerss

作　　者：谭玉凤[1] 吴南翔[1] 金锋[1] 楼建林[1] 陶核[1] 刘克澄[1] 宋杨[1] 

机构地区：[1]浙江省医学科学院,杭州市310013

出　　处：《职业与健康》2012年第16期1961-1962,共2页Occupation and Health

基　　金：浙江省科技条件建设项目(项目编号:2011F10016)

摘　　要：目的预防工人职业性锰中毒,寻找锰中毒早期预警指标。方法对148名职业性锰接触工人和100名对照人员进行了尿锰、尿锌水平的检测。结果锰暴露组人群与对照组尿锰差异无统计学意义(t=0.195,P>0.05;尿锌暴露组显著低于对照组,分别为(2.08±0.48)和(3.21±0.64)μmol/L,差异有统计学意义(t=15.15,P<0.01);而尿锌浓度随尿锰浓度升高而降低,呈负相关(P<0.01)。结论过量锰可能影响人体内锌的正常代谢,尿锌浓度的检测对于锰中毒的早期诊断具有参考意义。[Objective]To prevent occupational manganese poisoning of workers,and look for early warning indicators of manganese poisoning.[Methods]Urine manganese and zinc levels detection was performed on 148 workers with occupational exposure and 100 controls.[Results] There was no significant difference of urine manganese level between manganese exposure group and the control group（t=0.195,P0.05）.Urine zinc level of zinc exposure group（2.08±0.48） μmol/L was significantly lower than that of control group（3.21±0.64） μmol/L（t=15.15,P0.01）.Urine zinc level decreased with increasing level of urine manganese,showing negative correlation（P0.01）.[Conclusion]Excessive manganese level can affect the normal metabolism of human body.Urinary zinc level detection has reference value in early diagnosis of manganese poisoning.

关 键 词：职业健康检查 尿锰、锌代谢 

分 类 号：R135.1[医药卫生—劳动卫生]