关于高血压患者血清HGF、sICAM-1水平的研究(英文)  

Study for serum levels of hepatocyte growth factor and soluble intercellular adhesion molecule-1in patients with hypertension

作　　者：李奕宏[1] 金梅花[1] 于爽[1] 于波[2] 

机构地区：[1]佳木斯大学附属第一医院循环内科,黑龙江佳木斯154002 [2]佳木斯市中心医院

出　　处：《心血管康复医学杂志》2012年第4期345-348,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨高血压患者血清肝细胞生长因子(HGF),可溶性细胞间黏附分子-1(sICAM-1)水平的变化及其意义。方法:选择59例高血压患者,其中高血压1级组20例,高血压2级组19例,高血压3级组20例,并选择30例健康体检者作为正常对照组。用酶联免疫双抗体夹心法检测各组血清HGF和sICAM-1浓度,并进行比较。结果:与正常对照组相比,高血压患者血清HGF[(641.65±142.90)pg/ml比(998.15±241.38)pg/ml]、sI-CAM-1[(161.70±32.36)ng/ml比(327.17±31.28)ng/ml]水平明显升高(P<0.01),血压越高,其变化越显著(P<0.01),HGF浓度与sICAM-1浓度呈正相关(r=0.317,P<0.01)。结论:HGF与sICAM-1可能参与了高血压的发病过程,而且HGF在高血压内皮细胞损伤的修复中可能具有重要作用。Objective ： To study changes of serum levels of hepatocyte growth factor（HGF）,soluble intercellular adhesion molecule-1（sICAM-1） in patients with essential hypertension（EH） and their significance.Methods ： A total of 59 EH patients were selected,including 20 cases with EH stage 1（EH stage 1 group）,19 cases with EH stage 2（EH stage 2 group） and 20 cases with EH stage 3（EH stage 3 group）.Another 30 healthy subjects were regard as normal control group.Double antibody enzyme-linked immunosorbent sandwich assay was used to measure concentrations of HGF and sICAM-1 in all groups,and then the results were compared and analyzed.Results ： Compared with normal control group,there were significant increase in serum levels of HGF [（641.65±142.90） pg / ml vs.（998.15±241.38） pg / ml ] and sICAM-1 [（161.70±32.36） ng / ml vs.（327.17±31.28） ng / ml ] in EH patients（P 0.01 both）,and it′s more significant as blood pressure increased（P0.01）.HGF concentration was positively correlated with sICAM-1 concentration（r=0.317,P0.01）.Conclusion ： HGF and sICAM-1 may participate in pathogenesis of hypertension,and HGF may play an important role in restore of impaired endothelial cells in hypertension.

关 键 词：胞间粘附分子-1 高血压 肝细胞生长因子 

分 类 号：R544.109[医药卫生—心血管疾病]