高敏C反应蛋白与急性冠脉综合征的相关性  

Correlation between hsCRP and acute coronary syndrome

作　　者：王曼[1] 李建伟[1] 卓鹏展[1] 

机构地区：[1]西安市第四医院心内科,陕西西安710004

出　　处：《心血管康复医学杂志》2012年第4期376-379,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨高敏C反应蛋白(hsCRP)与急性冠脉综合征(ACS)病变严重程度及预后之间的关系。方法:选择95例ACS患者,其中急性心肌梗塞(AMI)50例、不稳定型心绞痛(UAP)45例,并根据冠脉病变程度分单支血管病变(SVL)组48例和多支血管病变(MVL)组47例。另选40例非ACS患者作为非ACS对照组,测定各组hsCRP、纤维蛋白原、血脂等指标,进行比较。结果:与非ACS对照组比较,UAP组、AMI组hsCRP水平明显升高[(0.85±0.49)mg/L比(10.01±1.73)mg/L比(52.73±2.39)mg/L,P<0.01],AMI组明显高于UAP组(P<0.01);MVL组hsCRP水平明显高于SVL组[(69.11±1.98)mg/L比(10.12±2.01)mg/L,P<0.05]。Spearman相关分析显示,hsCRP与冠脉狭窄呈正相关(r=0.210,P=0.042),与纤维蛋白原(r=0.516,P<0.0001)、血脂水平呈明显正相关(r=0.100～0.159,P<0.001～<0.0001)。结论:高敏C反应蛋白与冠脉病变严重程度呈正相关,是冠心病的独立危险因素;测定高敏C反应蛋白水平对急性冠脉综合征的危险分层和预测病变严重程度具有较高的临床参考价值。Objective：To study relationship among severity,prognosis of acute coronary syndrome（ACS） and high sensitive C reactive protein（hsCRP）.Methods： A total of 95 ACS patients were enrolled,including 50 cases with acute myocardial infarction（AMI,AMI group） and 45 cases with unstable angina pectoris（UAP,UAP group）.According to lesion of coronary artery,patients were divided into single vessel lesion（SVL） group（n=48） and multiple vessel lesion（MVL） group（n=47）.Another 40 non-ACS patients were regard as non-ACS control group.Levels of hsCRP,fibrinogen and blood lipids were measured and compared among all groups.Results：Compared with non-ACS control group,there were significant increase in hsCRP level in UAP group and AMI group [（0.85±0.49） mgL vs.（10.01±1.73） mgL vs.（52.73±2.39） mgL,P0.01],and that of AMI group was significantly higher than that of UAP group（P0.01）;hsCRP level in MVL group was significantly higher than that of SVL group [（69.11±1.98） mgL vs.（10.12±2.01） mgL,P0.05].Spearman correlation analysis indicated that hsCRP was positively correlated with coronary stenosis（r=0.210,P=0.042）,fibrinogen（r=0.516,P0.0001） and blood lipid levels（r=0.100～0.159,P0.001～0.0001）.Conclusion： High sensitive C reactive protein is positively correlated with severity of coronary disease and an independent risk factor for coronary heart disease;measurement of its level contributes to risk classification and prediction of disease severity in acute coronary syndrome.

关 键 词：C反应蛋白质 冠状动脉疾病 危险因素 

分 类 号：R541.409[医药卫生—心血管疾病]