接触系统生物学意义的再认识  

Revision of the Biological Significance of the Contact System

作　　者：刘发益[1] 贺石林[1] 

机构地区：[1]湖南医科大学生理学教研室,长沙410078

出　　处：《生理科学进展》2000年第1期7-12,共6页Progress in Physiological Sciences

摘　　要：目前,凝血学说发生了概念性改变,认为体内凝血过程分为两个阶段,组织因子途径负责凝血过程的启动,以因子Ⅺ(FⅪ)为起点的内在途径负责凝血过程的放大,而接触系统并不参与体内凝血过程。已有资料表明,接触系统是一个重要的血管生物学调制系统。它的主要作用包括调整血管紧张度、抑制血小板活化、促进纤溶、抑制粘附以及促进炎症等。它的改变与败血症、血栓性疾病等病变过程密切相关。Current concept of blood coagulation is divided into two stages: an “initiation” stage which is handled by tissue factor pathway, and an “augmentation” stage handled by intrinsic pathway beginning in factor Ⅺ. Recent studies have demonstrated that the contact system is a modulator for vascular biology with vascular tone regulation, anticoagulant, profibrinolytic, antiadhesive and proinflammatory functions. Changes of contact system are associated with sepsis, thrombosis, etc.

关 键 词：接触系统 细胞因子途径 血管生物学 调制系统 

分 类 号：R331.32[医药卫生—人体生理学] R554[医药卫生—基础医学]