老年反复呼吸道感染患者T淋巴细胞亚群变化及胸腺肽α_1干预研究  

T lymphocyte subsets changes and the intervention study of thymosin α_1 in elderly patients with recurrent respiratory tract infections

作　　者：陆卫东[1] 殷少军[1] 祝炜[1] 李瑾[1] 李微[1] 樊美红[1] 张毅琴[1] 林桦[1] 董福轮[1] 

机构地区：[1]同济大学附属第十人民医院老年科,上海200072

出　　处：《实用药物与临床》2012年第8期470-472,共3页Practical Pharmacy and Clinical Remedies

基　　金：上海市干部保健局科研基金资助项目(2011GB24)

摘　　要：目的观察老年反复呼吸道感染患者T淋巴细胞亚群变化及胸腺肽干预对其免疫功能的影响。方法将46例老年反复呼吸道感染患者分为治疗组和对照组,各23例,治疗组在常规治疗下,加用胸腺肽α11.6 mg皮下注射,每周2次,6个月为1个疗程。对照组给予常规治疗。比较两组间呼吸道感染发生情况及T淋巴细胞亚群变化。结果治疗后,治疗组CD3、CD4及CD4/CD8升高,CD8下降。与对照组比较,治疗组发生呼吸道感染次数减少,程度降低(P<0.01)。结论胸腺肽α1预防和治疗老年反复呼吸道感染具有良好的临床疗效,可改善T淋巴细胞亚群免疫功能。Objective To investigate the T lymphocyte subsets changes and the effects of immunologic function of thymosin α1 intervention on elderly patients with recurrent respiratory tract infections.Methods 46 elderly patients with recurrent respiratory tract infections were randomly assigned to receive thymosin α1（1.6 mg subcutaneous injection twice per week with 6 months of a period of treatment）combined with conventional therapy（treatment group,n=23）or conventional therapy（control group,n=23）.All the patients received 6 months follow-up.The occurrence of respiratory tract infection and the changes of T lymphocytes subsets of the two groups were compared.Results After treatment,CD3,CD4 and CD4/CD8 in treatment group increased,while the CD8 decreased.The number and degree of respiratory infection in treatment group were less than those of control group（P0.01）.Conclusion The prevention and curative effect of thymosin α1 on elderly patients with repeated respiratory infections is good,thymosin α1 can improve the immune function of T lymphocyte subsets.

关 键 词：呼吸道感染 T淋巴细胞亚群 胸腺肽Α1 老年人 

分 类 号：R725.6[医药卫生—儿科]