抑郁症患者血清脑源性神经营养因子水平及其相关因素  

An analysis of serum levels of BDNF and related factors in depressive patients

作　　者：孙喜蓉[1] 瞿正万[1] 蔡正宜[1] 傅伟忠[1] 林霞凤[1] 王豪[1] 陈福珍[1] 秦虹云[1] 

机构地区：[1]上海市浦东新区精神卫生中心,200124

出　　处：《神经疾病与精神卫生》2012年第4期341-343,共3页Journal of Neuroscience and Mental Health

基　　金：基金项目：上海市浦东新区卫生局卫生科技项目（PW2009A--29）

摘　　要：目的探讨抑郁症患者血清脑源性神经营养因子水平及其相关因素，为防治抑郁症提供重要依据。方法采用酶联免疫吸附法和汉密尔顿抑郁量表分别测定40例抑郁症患者（患者组）的血清BDNF水平和抑郁严重程度，并与49名正常者（对照组）进行对比分析。结果患者组治疗前血清BDNF水平明显降低，与对照组比较差异有统计学意义（P〈0．01）。患者组治疗8周末血清BDNF水平明显升高，HAMD总分明显降低，与治疗前比较差异有统计学意义（P〈0．05）。患者组治疗前后血清BDNF水平与性别及年龄均呈负相关，差异具有统计学意义（P〈0．05），与受教育程度、病程及HAMD总分比较无统计学意义（P〉0．05）。结论抑郁症患者存在血清BDNF水平的下降，抗抑郁治疗可改善抑郁症状，并显著提高血清BDNF水平。Objective To explore the serum＇levels of Brain--derived neurotrophic factor （BDNF） in patients with depression. Methods Serum BDNF levels were measured in 40 depression and 48 healthy controls. The severities of depression were measured with the 17--item Hamilton Rating Scale for Depression （HAMD-17）, before and after antidepressant treatment, respectively. Results The participants with depression had lower Serum BDNF levels than the controls （P〈0.01）, and increased significantly at the end of 8 weeks after treatment（P〈0.05）, with decreased HAMD--17（P〈0.01）. It was estimated that the Serum BDNF levels had negative relationship with sex and age（P〈0.05）, whereas no relationship with education, disease duration, and HAMD--17 scores（P〉0.05）. Conclusions The resuits indicate that, compared to antidepressant treatment, the patients with depression prior to treatment have worse executive function performance and lower Serum BDNF.

关 键 词：抑郁症 脑源性神经营养因子 因素 

分 类 号：R651.2[医药卫生—外科学]