耐碳青霉烯类鲍曼不动杆菌医院感染监测分析  

Surveillance for distribution and drug resistance of carbapenemase-resistance Acinetobacter baumannii causing nosocomial infections

作　　者：严冰[1] 韩艳萍[1] 张代惠[1] 廖映玲[1] 方锐[1] 蒋荔[1] 

机构地区：[1]深圳市第二人民医院院感科,广东深圳518035

出　　处：《实验与检验医学》2012年第4期327-329,共3页Experimental and Laboratory Medicine

基　　金：广东省自然科学基金资助项目;编号:915100890100041

摘　　要：目的探讨耐碳青霉烯类鲍曼不动杆菌(CRAB)引发的医院感染分布及耐药性,为寻求更有效的预防和控制方式提供科学依据。方法采用回顾性调查的方法,对2010年至2011年深圳市第二人民医院医院感染病例中鲍曼不动杆菌(ABA)引发的医院感染中CRAB的分布及耐药情况进行分析。结果两年医院感染病例共分离137株CRAB菌株,其中以呼吸道标本的来源居第一位,分离率为67.9%;科室分布以重症监护病房(ICU)分离率最高,为57.7%,其次是神经外科病房,为21.9%。结果显示CRAB菌株呈现高度耐药性,对头孢吡肟、头孢他啶、哌拉西林/他唑巴坦、氨苄西林/舒巴坦、阿米卡星、庆大霉素、左氧氟沙星、环丙沙星等耐药率均在90%以上,而对米诺环素耐药率最低,为2.2%,其次是头孢哌酮/舒巴坦,耐药率为44.5%。结论应继续加强CRAB监测,要重点关注ICU病房及呼吸系统医院感染的预防控制。Objective To investigate the distribution and drug resistance of carbapenem-resistance Acinetobacter baumannii （CRAB） so as to provide scientific reference for clinical treatment and control of nosocomial infections. Methods Of 137 strains of CRAB causing nosocomial infetions collected from 2010 to 2011 in Shenzhen Second People＇s Hospital,the drug resistance rate and the distribution were analyzed retro- spectively. Results Among 137 strains of CRAB causing nosocomial infections, 93 isolates were obtained from the respiratory tract specimens（67.9%）; CRAB strains were mostly distributed in ICU（57.7%）,followed by neu- rosurgery （21.9%）. The resistance rates of the 137 stains of CRAB to cefepime, ceftazidime, piperacillin/ tazobactam, ampicillin-sulbactam, amikacin, gentamicin, levofloxacin, and ciprofloxacin were higher than 90%, the lowest one was minocycline（2.2%）, and the second-to-last one was cefoperazone/sulbactam（44.5%）. Con- clnsion The surveillance of CRAB should be further strengthened, it is necessary to focus on the control and prevention of nosocomial infections of ICU unit and respiratory system.

关 键 词：碳青霉烯 鲍曼不动杆菌 医院感染 

分 类 号：R446.5[医药卫生—诊断学] Q939.92[医药卫生—临床医学]