滋肾益经活血汤治疗卵巢早衰患者50例临床观察  

Clinical Observation of 50 Cases of Premature Ovarian Failure Treated with Zishen Yijing Huoxue Tang

作　　者：张文红[1] 赵彦鹏[1] 李果[2] 冯俊婵[1] 沈华[1] 韩丽娟[1] 

机构地区：[1]山西中医学院附属医院,山西太原030024 [2]中国人民解放军第一医院,甘肃兰州730030

出　　处：《世界中西医结合杂志》2012年第8期670-671,705,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：山西省卫生厅科技攻关计划项目(No.200701)

摘　　要：目的观察滋肾益经活血汤治疗卵巢早衰的临床疗效。方法将100例患者随机分为两组,治疗组(50例)用滋肾益精活血治疗,对照组(50例)给予六味地黄丸。两组均以3个月为1个疗程,连续治疗2个疗程,对比两组治疗后的总有效率,血清IL-2、TNF-α、E2、FSH、LH水平,卵巢血流动力及临床症状积分。结果治疗组总有效率为96.0%,对照组为62.0%,两组比较差异有统计学意义(P<0.05);治疗组与对照组均能够提高血清IL-2、TNF-α、E2水平,降低血清FSH、LH水平,两组治疗后比较,差异有统计学意义(P<0.05);与对照组比较,治疗组能明显改善卵巢的血流动力,两组差异有统计学意义(P<0.05);在改善临床症状积分方面,两组比较差异有统计学意义(P<0.05)。结论滋肾益经活血汤治疗卵巢早衰的临床疗效显著。Objective To observe the clinical efficacy on premature ovarian failure （POF）treated with zishen yijing huoxue tang. Methods 100 cases were randomized into two groups. In a treatment group （50 cases） , zishen yijing huoxue tang was prescribed. In a control group（ 50 cases） , liuwei dihuang wan was prescribed. The treatment of 3 months was taken as 1 session in two groups. The treatment lasted for 2 sessions. The total effective rate, the levels of serum 1L - 2, TNF - a, E2, FSH and LH, the dynamic ovarian blood flow and clinical symptom score were compared between two groups after treatment. Results The total effective rate was 96.0% in the treatment group and was 62.0% in the control group,presenting the statistical significant difference in comparison （ P 〈 0.05 ）. The treatments in either group could improve the levels of serum IL -2,TNF - a, E2, FSH and LH. The differences in the results after treatment were significant staffstically in comparison between two groups（P 〈0.05 ）. Compared with the control group, the treatment in the treatment group remarkably improved the dynamic ovarian blood flow, presenting the statistical significant difference（P 〈 0.05）. The improvement of the clinical symptom scores indicated the statistical significant difference in comparison between two groups （ P 〈 0.05 ）. Conclusion Zishen yijing huoxue tang achieves the significant clinical efficacy on POF.

关 键 词：滋肾益经活血汤 卵巢早衰 IL-2、TNF-α 

分 类 号：R285.6[医药卫生—中药学] R711.75[医药卫生—中医学]