养血注射液的血液流变学及其一般药效学试验研究  

Experimental study on hemorheology and pharmacodynamics of the Yangxue injection

作　　者：李孝栋[1] 侯超[1] 

机构地区：[1]福建中医药大学药学院,福建福州350108

出　　处：《中医临床研究》2012年第16期27-30,共4页Clinical Journal Of Chinese Medicine

基　　金：福建省科技平台建设;项目编号:2010Y2004

摘　　要：目的:研究养血注射液降低血液粘度的作用及其安全性。方法:通过大鼠血液流变学试验观察养血注射液对血液粘度的降低作用,并开展急性毒性和溶血试验,确定注射液的安全性。结果:养血注射液高剂量组能降低高、中、低切血液粘度和血浆粘度,中剂量组效果能降低中、低切血液粘度和血浆粘度,低剂量组能降低低切血液粘度和血浆粘度;小鼠尾静脉注射LD50=36.57ml/kg,3批溶血试验,溶血率均低于3.5%,符合规定。结论:养血注射液能够很好地降低血液粘度,具有毒性小、溶血率低、安全性好的特点。Objective： To investigate the role of Yangxue injection to reduce blood clotting and its safety. Methods： The rat blood rheology experiment, observed the role of the Yangxue injection to decreased blood viscosity, and carrying out the acute toxicity and hemolysis test, to determine the safety of the injection. Results： The high dose group of injection can reduce the whole blood viscosity at high, middle and low shear rates and plasma viscosity. The middle dose of group can reduce the whole blood viscosity at middle and low shear rates and plasma viscosity and the low dose of group can reduce the whole blood viscosity at low shear rates and plasma the mice LDs0 through intravenous injection was 36.57ml/kg. Hemolysis rate were all less than 3.5% in hemolysis test with three batches of injection samples, in line with the provisions. Conclusion： Yangxue injection can reduce blood viscosity well with good dose-effect relationship, which was safe to use with little toxicity and low hemolysis rate.

关 键 词：养血注射液 治未病 血液流变学 急性毒性 溶血 

分 类 号：R28[医药卫生—中药学]