体质量指数、腰臀比及腰围与慢性乙型肝炎并非酒精性脂肪性肝病的相关性研究  

The correlation between body mass index,waist-to-hip ratio,waist circumference chronic hepatitis B with nonalcoholic fatty liver diseases

作　　者：郑瑞丹[1] 陈卓然[1,2] 陈建能[1] 卢燕辉[1] 陈洁[1] 

机构地区：[1]厦门大学附属东南医院肝病治疗中心,漳州市363000 [2]厦门大学公共卫生学院08级预防医学系

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第4期46-49,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：福建省漳州市科技计划资助项目(No.Z04094)

摘　　要：目的探讨体质量指数(BMI)、腰臀比(WHR)与慢性乙型肝炎(CHB)并非酒精性脂肪性肝病(NAFLD)的相关性。方法研究对象为厦门大学附属东南医院肝病中心住院的110例NAFLD患者和143例CHB并NAFLD患者,选取同期健康体检者23例为对照组。采用方差分析(ANOVA)、Bonferroni法,比较三组间BMI、WHR、腰围(WC)、空腹血糖(FBG)、胆固醇(TCHO)、甘油三酯(TG)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、谷氨酰转移酶(GGT)的差别,分析各项指标与CHB并NAFLD的相关性。结果与对照组相比,NAFLD组和CHB并NAFLD组的BMI、WHR、WC、TG、AST、ALT、GGT水平均显著增加(P<0.05)。NAFLD组的WHR和WC值显著高于CHB并NAFLD组,其余指标差异均无统计学意义(P>0.05)。结论 CHB并NAFLD患者的发病机制与血脂紊乱相关,尤其是高TG血症,临床中监测WHR与WC有助于CHB并NAFLD的早期诊断。Objective To explore the correlation between body mass index （BMI）, waist to hip ratio （WHR） and chronic hepatitis B （CHB） patients with nonalcoholic fatty liver diseases （NAFLD）. Methods A total of 110 subjects with NAFLD and 143 CHB patients with NAFLD were enrolled in Dongnan Affiliated Hospital of Xiamen University, and 23 normal subjects were selected as control group. Differences of BMI, WHR, waist circumference （WC）, fasting plasma glucose （FPG）, total cholesterol （TCHO）, triglyceride （ TG ）, aspartate aminotransferase （ AST ）, alanine aminotransferase （ ALT ）, alkaline phosphatase （ALP）, gamma-glutamyl transpeptidase （GGT） among three groups were analyzed by ANOVA and Bonferroni correction methods. Results Compared with the control group, the levels of BMI, WHR, WC, TG, AST, ALT, GGT were significantly higher in CHB patients with NAFLD and NAFLD patients （ P 〈 0.05 ）. WHR and WC of NAFLD patients were higher than that of CHB patients with NAFLD. There was no significant difference in other indexes. Conclusions The hepatic steatosis changes in CHB patients with NAFLD are mainly caused by the metabolic factors. WHR and WC may be helpful for early diagnosis in CHB patients with NAFLD.

关 键 词：肝炎 乙型 慢性 肝病 非酒精性 脂肪性 体质量指数 腰臀比 腰围 

分 类 号：R512.62[医药卫生—内科学] R575.5[医药卫生—临床医学]