酞咪哌啶酮和抗结核药物治疗肺结核的近期疗效分析  

Analysis on short term efficacy of antituberculous drugs and thalidomide therapy for patients with pulmonary tuberculosis

作　　者：李继瑞[1] 谢学磊 魏明[1] 袁冶[1] 李翼[1] 郭义平[1] 黄晴[1] 王艳秋[1] 刘炜[1] 胡智敏[1] 黄正辉[1] 郭晓红[1] 康亮[1] 

机构地区：[1]武汉市医疗救治中心,武汉市430023

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第4期76-78,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：2007年度武汉市公共卫生科研项目(No.11)

摘　　要：目的探索酞咪哌啶酮和抗结核药物治疗肺结核的疗效。方法将117例肺结核初治患者随机分成两组,治疗组患者给予常规抗结核药物加酞咪哌啶酮治疗;对照组患者给予常规抗结核药物治疗。肺结核初治患者(非孕女性)治疗2周后作常规复查(包括TNF-α、IL-1、胸部X片、痰涂片、血常规、肝肾功能等指标)以观察其治疗效果。结果治疗组患者的依从性好,不良反应少,2周内痰结核分枝杆菌阴转率高且快(P<0.05),疗效明显。结论酞咪哌啶酮作为抗结核治疗常规药物可迅速改善患者的临床症状并加快疾病康复进程。Objective To explore the clinical effects of antituberculous drugs and thalidomide on patients with pulmonary tuberculosis. Methods Total of 117 patients with pulmonary tuberculosis who were treated initially were divided into two groups were randomly, patients in the treatment group were treated with antituberculous drugs and thalidomide while the control group with antitubereulous drugs. All patients treated for two weeks and then the indexes of TNF-oL, IL-1, chest X, plan sputum smear, blood routine examination, liver and kidney function were detected in order to investigate on the clinical effects. Results The treatment group had a good compliance and little adverse reactions. The negative conversion rate of mycobacterium tuberculosis in treatment group was significantly higher （ P 〈 0.05 ）, suggesting that the treatment method was effective. Conclusions Thalidomide as conventional antibubereulosis drugs can rapidly improve the clinical symptoms of the patients and accelerate the rehabilitation process.

关 键 词：结核 肺 酞咪哌啶酮 疗效 

分 类 号：R521[医药卫生—内科学]