肾上腺素、异丙肾上腺素雾化治疗早产儿撤机后喉头水肿的疗效  

Effect of Inhaled Epinephrine, Isoproterenol on Laryngeal Edema in Preterm Infants Extubated after Mechanical Ventilation

作　　者：关浩锋[1] 刘郴州[1] 刘东[1] 郭青云[1] 黄碧茵[1] 林丽丹[1] 

机构地区：[1]广东省江门市中心医院,广东江门529070

出　　处：《中国医学创新》2012年第24期23-24,共2页Medical Innovation of China

摘　　要：目的:观察肾上腺素、异丙肾上腺素雾化吸入治疗机械通气早产儿拔管后喉头水肿的临床疗效。方法:选择2009年3月-2012年3月在本院进行机械通气的拔管后出现喉头水肿症状的早产儿160例,随机分入治疗组与对照组各80例,治疗组给予肾上腺素、异丙肾上腺素雾化吸入,对照组给予万托林、异丙托溴铵、布地奈德雾化吸入,观察喉头水肿症状持续时间、雾化吸入后1h的动脉氧分压、二氧化碳分压、呼吸频率和心率。结果:治疗组喉头水肿症状持续时间为(27.60±15.38)h,对照组为(34.94±19.53)h,治疗组症状持续时间较对照组短,两组比较,差异有统计学意义(t=2.641,P<0.05);雾化后1h治疗组氧分压为(85.15±24.19)mmHg,对照组为(77.60±17.09)mmHg,治疗组氧分压较对照组高,两组比较,差异有统计学意义(t=2.280,P<0.05);治疗组二氧化碳分压为(43.70±8.52)mmHg,对照组为(47.03±9.55)mmHg,治疗组二氧化碳分压较对照组低,两组比较,差异有统计学意义(t=2.325,P<0.05);治疗组呼吸频率为(49.59±7.79)次/min,对照组为(52.33±7.76)次/min,治疗组呼吸频率较对照组低,两组比较,差异有统计学意义(t=2.227,P<0.05);治疗组心率为(146.95±14.22)次/min,对照组为(148.86±14.78)次/min,两组比较,差异无统计学意义(t=0.834,P>0.05)。结论:肾上腺素、异丙肾上腺素雾化吸入可以缩短喉头水肿症状持续时间,提高动脉血氧分压,降低二氧化碳分压,降低呼吸频率。Objective： To observe the clinical effect of inhaled epinephrine, isoproterenol on laryngeal edema in preterm infants extubated after mechanical ventilation. Method： 160 preterm infants who had laryngeal edema symptoms, extubated after mechanical ventilation, chosen From March 2009 to March 2012 in The Jiangmen affiliated Hospital of Sun Yet-sen University, were randomly divided into treatment group（TG, n=80） and control group（CG, n=80）. The TG received epinephrine, isoproterenol aerosol inhalation, and the CG was given ventolin, ipratropium bromide and budesonide aerosol inhalation. The duration of laryngeal edema symptoms, arterial oxygen partial pressure, carbon dioxide partial pressure, respiratory rate and heart rate were observed after 1 hour. Result： The duration of laryngeal edema symptoms of the TG was （27.60 ± 15.38）h, CG was （34.94 ± 19.53） h, the duration of symptoms of TG was shorten, the difference between the two groups was statistically significant（t=2.641, P〈0.05）. After 1 hour treatment, arterial oxygen partial pressure of the TG was （85.15±24.19）mm Hg, the CG was （77.60± 17.09）mm Hg, the oxygen partial pressure Of TG was higher with significant difference （t=2.280, P〈0.05）. Carbon dioxide partial pressure of the TG was （43.70 ± 8.52）mm Hg, the CG was （47.03 ± 9.55）mm Hg, the carbon dioxide partial pressure of TG was lower with significant difference （t=2.325, P〈0.05）. Respiratory rate of the TG was （49.59 ±7.79）times/min, the CG was （52.33 ±7.76）times/min, the respiratory rate of TG was lower, which the difference was statistically significant（t=2.227, P〈0.05）. Heart rate of the TG was （146.95 ± 14.22）beats/min, the CG was （148.86± 14.78） beats/min, the difference was not statistically significant（t=0.834, P〉0.05）. Conclusion： Epinephrine, isoproterenol aerosol inhalation can shorten the duration of the symptoms of laryngeal edema and improve arterial oxygen partial pressure, reduce carbon dioxide pa

关 键 词：肾上腺素 异丙肾上腺素 早产儿 机械通气 喉头水肿 

分 类 号：R722.6[医药卫生—儿科]