胎儿生长受限对生殖功能的影响  

Influence of fetal growth restriction on reproductive function

作　　者：乔谷媛[1] 马向东[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032

出　　处：《中国妇幼健康研究》2012年第4期544-546,共3页Chinese Journal of Woman and Child Health Research

摘　　要：胎儿生长受限（FGR）围产儿患病率和死亡率均高于正常儿童，其成年后发生慢性疾病风险升高。出生后的生殖能力可能大部分由胎儿时期的下丘脑-垂体-性腺轴系所决定。因此，出生前宫内的程序化改变会对成人后的生殖及内分泌造成影响。胎儿生长受限男性与隐睾症、睾丸癌等疾病的发生相关，会导致生育力下降；胎儿生长受限女性可能出现青春期发育过早、生育力低下，高雄激素血症、肾上腺皮质功能亢进、胰岛素敏感性降低。该文就胎儿生长受限对其生殖功能的影响进行综述。The perinatal morbidity and mortality of infants with fetal growth restriction （FGR） are higher than those of normal infants, and their risk of developing chronic diseases in adult increases. The postnatal reproductive function may be determined by hypothalamicpituitary-gonadal axis during fetal life, so malnutrition during critical period in uterus can influence reproduction and endocrine. To males, FGR is associated with diseases such as cryptorchidism and testicular cancer, and it may cause poor fertile ability. To females, early pubertal development, subfertility, hyperandrogenism, hypercorticism and decreased insulin sensitivity might occur. This article reviewed the influence of FGR on reproductive function.

关 键 词：胎儿生长受限 青春期 生殖 胰岛素抵抗 

分 类 号：R714[医药卫生—妇产科学]