胃旁路术SD大鼠实验动物模型的建立及其对体重的影响  

SD Rat Gastric Bypass Animal Model Establishment and RYGB Impact on Weight Reduction

作　　者：王一龙[1] 姜明哲[2] 陈登刚[2] 蔡景理[3] 谢杰斌[2] 李立军[3] 陈荣[2] 刘长宝[2] 

机构地区：[1]温州医学院动物实验中心,浙江温州325000 [2]温州医学院附属第二医院肛肠外科,浙江温州325000 [3]温州医学院附属第二医院普外科,浙江温州325000

出　　处：《世界最新医学信息文摘》2012年第3期1-4,共4页World Latest Medicine Information Electronic Version

基　　金：教育部高等学校博士点专项科研基金资助课题（20103321120001）;浙江省自然科学基金（Y2110335）;浙江省卫生厅医药卫生一般研究计划项目（201IKYA111）;温州市科技局基金（H20100058）

摘　　要：目的建立胃旁路术（RYGB）sD大鼠实验动物模型，初步探讨胃旁路术对SD大鼠体重减重的影响。方法将35只12周龄的雄性SD大鼠随机分为手术组（O）15只、假手术饮食控制组（C）10只及假手术空白对照组（B）10只。观察并记录各组大鼠术前及术后每天体重变化及每周进食量。结果O组大鼠死亡7只，存活率53．3％；O组大鼠在术后12天内体重下降幅度最大，其后体重出现反弹但较其他各组上升缓慢。结论通过sD大鼠建立胃旁路术动物模型是可行的，胃旁路术可有效控制SD大鼠体重。Objective：To establish the experimental animal model of gastric bypass surgery（RYGB） through the SD-rat,and to study the effect of gastric bypass surgery on weight reduction.Methods： Male rats （ 35 SD- rat ） were randomized into three groups：gastric bypass surgery was performed in 15 male SD rats as the study group（O group）,sham operation was performed in 10 SD male rats which diet control after operation as the study control group（C group）; and laparotomy was performed in 10 SD male rats which were given normal diet control after operation as the blank control group（B group）. Body weight and food intake were recorded before surgery and every day after surgery.Results：The number of death rats was 7 in the study group ,the survival rate is 53.3% , and the maximum weight loss was happened in the 12th days after surgery, Thereafter weight rebounded slower than group B and C（P〈0.05）.Conclusions：It is feasible to established gastric bypass surgery animal model through the SD rat. RYGB can control weight of SD-rat effectively.

关 键 词：动物模型 胃旁路术 减重 

分 类 号：R656.61[医药卫生—外科学]