左乙拉西坦添加治疗耐奥卡西平的部分性癫痫儿童疗效观察  

Effect of Levetiracetam as add-on therapy in Children with Oxcarbazepine Resistant Partial Epilepsy

作　　者：刘迪辉[1] 邓向红[1] 刘美玲[1] 李莹莹[1] 

机构地区：[1]中山市人民医院儿科,广东中山528400

出　　处：《世界最新医学信息文摘》2012年第7期19-21,共3页World Latest Medicine Information Electronic Version

摘　　要：目的探讨左乙拉西坦添加治疗对耐奥卡西平的部分性癫痫患儿的疗效及不良反应。方法对49例耐奥卡西平的部分性癫痫儿童添加左乙拉西坦治疗，按不同的耐药模式及发作类型进行疗效比较。结果全部病例总有效率59．18％，简单部分性发作组有效率71．43％，复杂部分性发作组有效率64．71％，部分性继发全面发作组有效率44．44％。三组有效率有显著性差异（P〈0．05）。从头耐药组与进展性耐药组间疗效无显著性差异。（P〉0．05）。结论：左乙拉西坦添加治疗对耐奥卡西平的部分性癫痫安全，有效。Objective To assess the efficacy and safety of Levetiracetam as add-on therapy in children with Ox- carbazepine resistant partial epilepsy. Methods 49 children with Oxcarbazepine resistant partial pilepsy were add-on treated with Levetiracetam, and the efficacy was compared according to different Oxearbazepine resis- tance pattern and different seizure type. Results The overall effective rate was 59.18%, there was significant difference among the three different seizure groups, （ P 〈 0.05）, with the best effective rate of 71.43% in simple partial seizure group, and the responsible rates was 64.71% and 44.44 % in complex partial seizure group and secondarily generalized seizure group respectively, there was no significant difference between the two resistance patterns. The side effects were mild. Conclusion： Levetiracetam was effective and safe as add-on therapy in chil- dren with Oxcarbazepine resistant partial epilepsy.

关 键 词：儿童 部分性癫痫 左乙拉西坦 奥卡西平 添加治疗 

分 类 号：R971.6[医药卫生—药品]