Epigenetic changes associated with oocyte aging  

作　　者：SCHATTEN Heide MA JunYu SCHATTEN Heide SUN QingYuan 

机构地区：[1]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]Department of Animal Sciences,Chungbuk National University,Cheongju 361-763 Republic of Korea [3]Department of Veterinary Pathoiology,Vniversity of Missouri,Columbia,MO 65211,USA

出　　处：《Science China(Life Sciences)》2012年第8期670-676,共7页中国科学（生命科学英文版）

基　　金：supported in part by the National Natural Science Foundation of China (Grant No. 81100422);National Basic Research Program of China (Grant Nos. 2012CB944404 and 2011CB944501)

摘　　要：It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age.Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process.Here,we review the epigenetic alterations,mainly focused on DNA methylation,histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age.Furthermore,we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age.Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process.Here,we review the epigenetic alterations,mainly focused on DNA methylation,histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age.Furthermore,we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.

关 键 词：FERTILITY advanced maternal age postovulatory oocyte aging DNA methylation histone modification 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]