Determinants of uterine aging:lessons from rodent models  

作　　者：KONG ShuangBo ZHANG Shuang CHEN YongJie WANG WeiXiang WANG BingYan CHEN Qi DUAN EnKui WANG HaiBin 

机构地区：[1]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]Graduate University of Chinese Academy of Sciences,Beijing 100039,China

出　　处：《Science China(Life Sciences)》2012年第8期687-693,共7页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China (Grant Nos. 2011CB944401 and 2010CB945002);the National Natural Science Foundation of China(Grant Nos. 30825015 and 81130009)

摘　　要：The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.

关 键 词：determinants uterine aging rodent models 

分 类 号：Q492.6[生物学—生理学] S823.2[农业科学—畜牧学]