肥大细胞与肾脏疾病  

Mast cells and kidney diseases

作　　者：王荣[1] 郑敬民[2] 

机构地区：[1]南京大学医学院临床学院 [2]南京军区南京总医院 全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2012年第4期366-369,378,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：近年来,肥大细胞在肾脏疾病中的作用逐渐受到关注,多种肾脏疾病患者肾组织中均发现肥大细胞增多,且肥大细胞数与多种临床病理指标及肾脏疾病顶后有显著相关性。动物实验也显示,肥大细胞可能在肾脏疾病的发生发展过程中起重要作用,其可能通过释放多种生物活性物质和与其他细胞直接作用参与肾脏疾病的发生发展,但肥大细胞在肾脏疾病中的确切病理意义和作用机制仍有待进一步研究。Recently, mast cells in kidney diseases have been a concern among nephrologists. Mast cells have been reported increased in the kidney of patients with renal diseases and correlated with clinical and pathological indices. Also, animal experiments have showed that mast cells may play an important role in the development of kidney diseases. It was believed that mast cells may exert their roles through releasing a variety of bioactive substances and/or contacting with other cells directly. However, the exact mechanism and pathological process remains to be elucidated.

关 键 词：肥大细胞 肾脏病 类胰蛋白酶 糜蛋白酶 

分 类 号：R692[医药卫生—泌尿科学]