东莞市无偿献血者甲型H1N1流感抗体血清学调查  

Serological survys on anti-H1N1 IgG of blood donors in Dongguan

作　　者：王德文[1] 刘赴平[1] 梁兵[1] 

机构地区：[1]广东省东莞市中心血站,523930

出　　处：《中华实验和临床病毒学杂志》2012年第4期263-265,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的评价无偿献血者接种甲流疫苗的持续免疫效果及未接种甲流疫苗献血者的甲流抗体水平，为防治甲流提供参考依据。方法应用ELISA法检测2010年1—6月1166例东莞市接种甲流疫苗及1265例未接种甲流疫苗的无偿献血者的甲流抗体。结果接种甲流疫苗献血者的平均甲流抗体的阳性率及高效价率为78．82％与46．57％，两者在71～90d达到峰值后维持在较高水平。未接种甲流疫苗献血者的平均甲流抗体阳性率为26．01％；在性别、年龄组别之间差异无统计学意义（P〉0．05）。结论甲流疫苗的持续免疫效果良好，对于甲流的防治有重要作用。未接种甲流疫苗献血者的甲流抗体阳性率低，应加强接种工作。Objective To access the sustained immune effect in influenza A H1N1 vaccine vaccinated-blood donors as well as the level of anti-H1N1 IgG in unvaccinated-blood donors in order to provide reference for preventing and treating influenza A H1N1. Methods Anti-H1N1 IgG was detected in 1166 vaccinated-blood donors as well as 1265 unvaccinated-blood donors by ELISA method in Dongguan from January 2010 to June 2010. Results The mean positive rate and high-titer rate of anti-H1N1 IgG were 78.82% and 46.57% respectively, both of which were sustained at relatively high level after reaching their peak at vaccination time of 71-90 d. The mean positive rate of anti-H1Nl IgG in unvaccinated-blood donors was 26. 01%. No difference was found in the positive rate of anti-H1N1 IgG among different gender or age groups（P 〉 0. 05）. Conclusion The influenza A H1NI vaccine, with good sustained immune effect, plays an important role in preventing and treating influenza A H1N1. The positive rate of anti-H1N1 IgG in influenza A H1N1 vaccine unvaccinated-blood donors is low. Vaccination should be strengthened.

关 键 词：流感病毒A型 人 供血者 流感疫苗 免疫 主动 

分 类 号：R446.6[医药卫生—诊断学]