乙型肝炎病毒感染者血清中丁型肝炎病毒标志物检测分析  

The analysis of hepatitis delta virus infective markers in the hepatit is B virus infective people

作　　者：许泼实[1] 韩双印[1] 孙长义[1] 赵静[1] 

机构地区：[1]河南省人民医院检验科,郑州450003

出　　处：《中华实验和临床病毒学杂志》2012年第4期307-309,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的了解丁型肝炎病毒（hepatitis delta virus，HDV）感染标志物在乙型肝炎病毒（hepatitis B virus，HBV）感染者中的分布状况并分析其临床意义。方法收集HBV感染者的临床资料和血清样本，通过酶联免疫分析法检测其血清HBV感染五项指标、HDVAg和Anti—HDV，结合临床诊断和生化指标进行分析。结果收集HBV感染者样本462例，其中无症状携带者210例，慢性肝炎175例，急性乙肝35例，肝纤维化42例，检出HDV感染率为4．8％，男性显著高于女性，肝纤维化组的HDV感染率最高，为9．5％，其次为慢性肝炎的6．9％，45—60岁人群的HDV感染率为7．8％，显著高于其他年龄段。结论慢性乙肝和肝纤维化病例的HDV感染显著增高，提示HDV感染与肝病的严重程度相关，建议对肝病患者开展血清HDV感染标志物检查，鉴别是否存在HDV重叠感染。Objective To investigate the distribution of hepatitis deha virus （HDV） marker among hepatitis B virus （HBV） infected patients and to reveal its clinical significance. Method To collect the clinical data and sera samples of HBV infected patients and to detect HDAg, Anti-HDV as well as HBV infection markers by means of enzyme-linked immunosorbnent assay. These data combined with clinical diagnostic results and biochemical index were then analyzed. Result 462 samples of HBV infected patients were collected including 210 HBV carriers without symptom, 175 chronic HBV infections, 35 acute HBV infections and 42 liver fibrosis. The HD~ infection rate was 4. 8% overall. The highest infection rate of 9.5% was found in the group of liver fibrosis whereas the lower rate of 6. 9% was found in HBV chronic carriers. HDV infection rate was 7.8% among the population of 40-60 years old, obviously higher than any other age groups. Conclusion HDV infection was significantly higher in the chronic HBV patients and liver fibrosis patients. Because HDV infection was highly associated with the progress of liver disease, we suggest the screen of HDV markers among hepatitis patients and discriminate whether the patient was co-infected with HDV.

关 键 词：肝炎病毒 乙型 δ肝炎病毒 血清学 

分 类 号：R51[医药卫生—内科学]