5-氨基酮戊酸光动力疗法治疗中重度痤疮疗效观察  

Efficacy of photodynamic therapy with 5-aminolevulinicacid in the treatment of moderate to severe acne

作　　者：陈向齐[1,2] 牛高祥[1,2] 刘向农[1,2] 陈进木[1,2] 吴洁[1,2] 陈胜平[1,2] 

机构地区：[1]福建医科大学福总临床医学院 [2]南京军区福州总医院皮肤科,福建福州350025

出　　处：《中国美容医学》2012年第9期1551-1553,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨5-氨基酮戊酸光动力疗法(5-aminolevul inicacid phot odynamic therapy,5-ALA-PDT)治疗中重度痤疮的疗效。方法:将50例中重度痤疮患者随机、单盲分为两组:治疗组给予5%浓度5-ALA敷药1.5h、照红光20min,每周1次,共治疗3次;对照组只给予红光照射,每周1次,共治疗3次。治疗后第2、4、6周对两组患者进行疗效判断和比较,并记录治疗过程中出现的不良反应。结果:治疗组24例完成疗程,第4、6周总有效率分别为75.0%(18例)、83.3%(20例),与对照组比较,具有显著性差异。结论:5%浓度5-ALA敷药1.5h、照光20mi n,每周1次、治疗3次能有效治疗中重度痤疮。Objective To investigate the efficacy and safety of 5-aminolevulinicacid photodynamic therapy in treatment of moderate to severe acne.Methods Fifty patients with moderate to severe acne were equally randomized into two groups,and one group was treated with 5% 5ALA-PDT with an interval of 1 week for 3 sessions while the other was only irradiated with red light once a week for 3 sessions.The patients were evaluated for efficacy after 2,4 and 6 weeks.Adverse effects were also recorded at each visit.Results 24 cases of treatment group completed treatment.The efficacy rate of 5-aminolevulinicacid photodynamic therapy during 4,6 weeks were 75.0%（18 cases）,83.3%（20 cases） respectably,which were higher than control group.Conclusions Topical 5-ALA-PDT has a significant effect in treatment of moderate to severe acne with few side reactions and it is more effective than the control group.

关 键 词：痤疮 5-氨基酮戊酸 光动力疗法 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]