白癜风10000例临床特征及治疗效果分析  

Clinical characteristics and therapeutic efficacy analysis on 10 000 cases of vitiligo

作　　者：坚哲[1] 李凯[1] 刘邦民[1] 李强[1] 刘玲[1] 宋璞[1] 王筱雯[1] 李舒丽[1] 石琼[1] 周福波[1] 栾琪[1] 马翠玲[1] 李春英[1] 高天文[1] 

机构地区：[1]第四军医大学西京皮肤医院,陕西西安710032

出　　处：《中国美容医学》2012年第9期1577-1580,共4页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金(30972642;81130032)

摘　　要：目的:总结与分析白癜风的临床特征和治疗效果,探讨白癜风发病机理。方法:采用调查表的形式收集10 000例白癜风患者的临床和治疗资料,从性别构成、发病年龄、病期、发病部位、皮损分布、皮损范围、皮损面积、诱发因素、疾病分期及分型、伴发疾病、家族史、发病或加重季节、细胞免疫水平、治疗效果等方面进行分析。结果:10 000例白癜风患者男女性别构成约为1.14:1,平均发病年龄为19.98岁,各年龄段均可发病,但约71%的患者在25岁以前发病,皮损多呈双侧分布,好发于躯干、四肢,多在夏季发病,约21%的患者发病前有明确的诱因。寻常型明显较节段型多,寻常型者中又以散发性为多;进展期者较稳定期者为多;1 294例有家族史;在各型白癜风中局限性白癜风疗效最佳。治疗6月后痊愈77例(4.65%),显效554例(33.47%),总有效率38.12%,好转955例(57.7%),无效69例(4.17%)。结论:白癜风患者发病年龄小,病因不清,部分患者有家族史或细胞免疫功能异常,疗效有待提高。Objective To evaluate clinical characteristics and therapeutic efficacy of vitiligo and probe into its pathogenesis.Methods Information on the clinical characteristics and therapeutic efficacy of patients with vitiligo were collected by a uniform questionnaire.Sex,onset age,duration of disease,occurrence site,lesion distribution,lesion stages,clinical type,lesion scope,lesion area,causes,complication,family history,occurrence season,the levels of cellular immunity and therapeutic efficacy were analyzed.Results 10000 patients with vitiligo were evaluated.The constitute rate of males to females was 1.14 ： 1,and the average onset age was 19.98 years old.The results showed that 71% cases betide before age 25.Trunk and limbs were the most sites of onset.The most frequent occurrence season is summer.About 21% have definite causes.The case of vitiligo vulgaris was more than the segmental type and the number of sporadic type was the most type in vitiligo vulgaris.Patients with progressive vitiligo were more than the patients in stable period.1294 cases had family history.The localized type presented better therapeutic efficacy.77 cases were fully recovered and 554 cases were markedly improved after treatment for 6 months.The total efficiency was 38.12%.Conclusion Patients with vitiligo had younger onset age and the etiology is unclear.Some patients have a family history or cellular immune dysfunction.The therapeutic efficacy remains to be improved.

关 键 词：白癜风 临床特征 治疗效果 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]