白癜风10821例伴发疾病的研究与分析  

Clinical profiles of vitiligo in China: an analysis of 10 821 patients with association diseases

作　　者：张雅君[1] 刘玲[1] 李强[1] 李凯[1] 刘邦民[1] 坚哲[1] 宋璞[1] 周福波[1] 王筱雯[1] 韦超[1] 石琼[1] 李舒丽[1] 尚磊[2] 马翠琳[1] 李春英[1] 高天文[1] 

机构地区：[1]第四军医大学西京皮肤医院,陕西西安710032 [2]第四军医大学军事预防医学系统计学教研室,陕西西安710032

出　　处：《中国美容医学》2012年第9期1589-1592,共4页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金(81000701;81130032)

摘　　要：目的:总结与分析白癜风伴发疾病的流行病学研究,分析不同类型的白癜风与其伴发疾病的关系,探讨白癜风的发病机制。方法:以调查表形式收集患者的临床资料10 821例,应用SPSS 19.0统计软件对资料进行统计学处理和分析。结果:10 821例白癜风患者中有743例出现伴发疾病,伴发率为6.87%。自身免疫性疾病是本研究中白癜风伴发率最高的一类疾病,共599例(5.54),其次为心血管系统疾病30例(0.28)。免疫系统疾病主要为甲状腺疾病(包括甲状腺功能低下及甲状腺功能亢进)85例(0.79),慢性肝炎65例(0.60),结缔组织病23例(0.21),糖尿病16例(0.15),斑秃44例(0.41)等。另外,伴发晕痣的患者达329例(3.04),是本次调查中伴发率最高的疾病。通过对比节段型与寻常型白癜风伴发上述疾病后,自身免疫系统疾病(P<0.05)、甲状腺疾病和慢性肝炎具有显著的统计学差异(P<0.05)。同时,白癜风伴发甲状腺疾病的女性患者54例(1.06)高于男性患者31例(0.54);伴发晕痣的患者中,白癜风皮损面积为轻度-中度有302例(3.25),多于中重度-重度患者27例(1.76);而伴发甲状腺疾病的患者中,皮损面积为轻度-中度60例(0.65),低于中重度-重度25例(1.63)。结论:白癜风伴发各类不同的系统性疾病,但多为与自身免疫相关或氧化应激相关的疾病,白癜风可能与这些伴发疾病有着共同的发病基础,为我们进一步研究白癜风的发病机制提供了更多的线索与依据。Objective To investigate patterns of association between type of vitiligo and common disease-related variables,in order to advance on the understanding of the exact nature of its pathogenesis.Methods This is a study of a population sample from Shaanxi province composed of 10821 vitiligo patients.Different vitiligo clinical types and age of onset,duration of disease,lesion distribution,lesion stages,lesion area and association diseases of patients with vitiligo were collected by a uniform questionnaire.Results Of this large cohort,743（6.87%） individuals presented vitiligo-associated diseases.599（5.54%） of the patients were associated with autoimmune diseases,followed by cardiovascular diseases 0.28%.329（3.04%）halo nevus were associated with vitiligo.Compared with the segmental vitiligo patients,the patients with generalized vitiligo were more likely to be affected by thyroid dysfunction（P0.01） and chronic hepatitis（P0.01）.More female patients（1.06%）were complicated by thyroidism diseases compared with male patients（0.54%）（P0.05）.The number of low-grade to medium-grade patients complicated with halo nevus was much larger than high-grade patients.However,it was contrary to vitiligo patients associated with thyroidism diseases.Conclusion A series of autoimmune and oxidative stress related diseases occur in vitiligo patients.As these associated diseases may have the same pathogenesis as vitiligo,it provides us more evidence for the further investigation of vitiligo.

关 键 词：白癜风 流行病学 伴发疾病 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]