秦菊滴眼液治疗家兔实验性结膜炎的实验研究  

Experimental study of Qinju eye drops on rabbits experimental conjunctivitis

作　　者：刘宏伟[1,2,3,4] 郭崧 王文 周毅[1,2,3,4] 

机构地区：[1]首都医科大学附属北京同仁医院 [2]北京同仁眼科中心 [3]北京市眼科学与视觉科学重点实验室 [4]北京市眼科研究所,北京100005 [5]北京博雅康泰生物工程科技有限公司

出　　处：《中国中医眼科杂志》2012年第4期239-241,共3页China Journal of Chinese Ophthalmology

基　　金：北京市科技计划课题资助项目(Y0204002041331)

摘　　要：目的观察中药制剂秦菊滴眼液对实验性结膜炎的治疗效果。方法采用结膜下埋线的方法,造成家兔结膜的炎症,使用含生药0.42 g/ml、0.21 g/ml和0.105 g/ml的秦菊滴眼液进行治疗,以溶剂为阴性对照,珍珠明目滴眼液为阳性对照。治疗前、治疗后第7天、第14天观察记录结膜病变和角膜病变情况。结果治疗后第14天,0.42 g/ml秦菊滴眼液组和珍珠明目滴眼液组的结膜病变轻于溶剂对照组,差异有统计学意义(P<0.05);0.42 g/ml秦菊滴眼液组和珍珠明目滴眼液组的治愈率高于溶剂组,差异有统计学意义(P<0.05)。结论 0.42 g/ml秦菊滴眼液对家兔实验性结膜炎有治疗作用。OBJECTIVE To examine the clinical effects of Qinju eye drops on rabbit experimental conjunctivitis.METHODS Conjunctivitis was prepared by subconjunctival line embedding.Qinju eye drops（0.42,0.21 and 0.105g/ml） were used for treatment,solutions for negative control and Zhenzhu Mingmu eye drops for positive control group.Conjunctival lesion and corneal lesion were examined and recorded before treatment and on the 7th and 14th day after treatment.RESULTS On the 14th day,the conjunctival lesions of Qinju（0.42g/ml） and Zhenzhu Mingmu eye drops group were significantly lighter than that of solutions group（P0.05）.The cure rates of Qinju（0.42g/ml） and Zhenzhu Mingmu eye drops group were significantly higher than that of solutions group（P0.05）.CONCLUSIONS Qinju eye drops（0.42g/ml） had some therapeutic effects on rabbit experimental conjunctivitis.

关 键 词：秦菊滴眼液 实验性结膜炎 治愈率 家兔 结膜下埋线 

分 类 号：R285.5[医药卫生—中药学] R777.31[医药卫生—中医学]