以水为提取溶媒中药半浸膏药料的制备工艺改进  

Improvement of Preparation Technology of Chinese Medicine Semi-extract with Water as Extraction Solvent

作　　者：刘明乐[1] 李克荣[1] 

机构地区：[1]湖北中医药大学附属襄阳市中医院,湖北襄阳441000

出　　处：《湖北中医药大学学报》2012年第4期30-32,共3页Journal of Hubei University of Chinese Medicine

摘　　要：目的简化中药半浸膏粉制备流程,降低劳动量,降低物料损耗率,提高药品均一性,减少受热对有效成分的破坏。方法选择2种制剂,以传统的工艺将中药饮片粉碎后与熬制好的流浸膏混合,再干燥粉碎,作为工艺Ⅰ;将传统工艺中需粉碎的中药饮片改为直接与熬制好的流浸膏混合,再干燥粉碎,作为工艺Ⅱ,分别制得2个品种共6个批次的中药胶囊剂。将2种工艺制备的半成品或成品从干燥粉碎次数、操作周期、物料损耗率、微生物限度检查和崩解时限等5个方面进行比较。结果工艺Ⅱ生产周期要短于工艺Ⅰ,工艺Ⅱ的物料损耗也优于工艺Ⅰ,同时2种工艺生产的成品其卫生学检测结果及崩解时限无显著差异,均合格。结论改进工艺优于常规工艺,值得推广。Objective To simplify the preparation process of semi -extract, reduce the amount of labor, lower material loss rate, im- prove the uniformity of drugs, and reduce heat damage to active ingredients. Methods Two kinds of preparations were chosen, one of which was traditional Chinese medicine would be crushed and mixed with liquid extract, then dried grinding together, as the process I , the other was traditional Chinese medicine and liquid extract were mixed, then dried grinding together, as the process Ⅱ. Two varieties and six batches of traditional Chinese medicine capsules were obtained. Dry grinding times, the number of operating cycles, the material loss rate, microbial limit, and disintegration time of two kinds of semi - fabricated or finished products were compared. Results Production cycle of process Ⅱ was shorter than process Ⅰ ,and material loss of process Ⅱ was better than the process Ⅰ. Meanwhile, hygiene and disintegration for fin- ished products of two kinds of the process produces were no significant difference, both of which were eligible. Conclusion Improved tech- nology is superior to conventional technology, which is worth promoting.

关 键 词：中药胶囊剂 半浸膏粉 粉碎 药物处理 制剂工艺 

分 类 号：R283.3[医药卫生—中药学]