国产冻干水痘减毒活疫苗的免疫原性及接种1年后免疫持久性观察  

Observation on immunogenicity of domestic freeze-dried live attenuated varicella vaccine and immunity persistence one year after vaccination

作　　者：马瑞[1] 许国章[1] 潘兴强[1] 李晓海[1] 方挺[1] 

机构地区：[1]宁波市疾病预防控制中心,浙江宁波315010

出　　处：《疾病监测》2012年第8期601-603,共3页Disease Surveillance

基　　金：中华预防医学会公共卫生应用研究与疫苗可预防疾病科研项目(No.20101101)~~

摘　　要：目的观察国产冻干水痘减毒活疫苗的免疫原性及持久性。方法选择119名7～13岁儿童分为两组,分别接种国产和进口冻干水痘减毒活疫苗,采用血清抗体膜免疫荧光法测定血清中的抗水痘病毒抗体水平。结果接种国产疫苗和进口对照疫苗6周后,抗体几何平均滴度分别为1∶160.7和1∶204.0,免疫成功率分别为96.7%和100%,两组免疫成功率和抗体几何平均滴度差异均无统计学意义(P分别为0.596和0.496,);接种国产疫苗1年后抗体水平显著低于接种6周后的抗体水平(P<0.001)。结论国产疫苗与进口对照疫苗具有同样良好的免疫原性,但抗体水平会随着时间的延长而降低。Objective To evaluate the immunogenicity and immunity persistence of domestic freeze-dried varicella attenuated live vaccine（VarV-Fd）.Methods Totally 119 children aged 7-13 years were recruited in Ningbo and then divided into two groups.Domestic VarV-Fd and imported VarV-Fd were vaccinated respectively for the children in two groups and serum antibody levels to varicella-zoster virus were detected by antibody membrane immune-fluorescence assay.Results Six weeks after vaccination,the antibody geometric mean titer was 1∶160.7 in children receiving domestic VarV-Fd and 1∶204.0 in children receiving imported VarV-Fd,the difference had no statistical significance（P=0.596）.The effective rates of both vaccines were 96.7% and 100%,the difference had no statistical significance（P=0.496）.The antibody level of domestic VarV-Fd 1 year after vaccination was significantly lower than that 6 months after vaccination.（P0.001）.Conclusion Both the domestic of VarV-Fd and imported VarV-Fd had good immunogenicity,but the immunity level by domestic VarV-Fd will decrease over time.

关 键 词：水痘减毒活疫苗 免疫原性 免疫持久性 

分 类 号：R392[医药卫生—免疫学]